PHRM 825: Flipped Lecture Medication Terminology (Asthma/COPD)

Question 1

What does ICS mean?

Answer 1

Inhaled corticosteroid

Question 2

What do ICS do?

Answer 2

Prevent and control inflammation

Question 3

Are ICS long-term controllers or short-acting treatments?

Answer 3

Long-term

Question 4

What does LABA mean?

Answer 4

Long acting beta agonists

Question 5

What do LABAs do?

Answer 5

Increase cAMP resulting in bronchial smooth muscle relaxation and inhibition of hypersensitivity mediators from mast cells (histamines and leukotrienes)

Question 6

Are LABAs long-term controllers or short-acting treatments?

Answer 6

Long-term

Question 7

What does LAMA mean?

Answer 7

Long-acting Antimuscarinics

Question 8

What do LAMAs do?

Answer 8

block bronchoconstrictor effects of acetylcholine on M3 and M2 receptors

Question 9

Are LAMAs long-term controllers or short-acting treatments?

Answer 9

Long-term

Question 10

What do leukotriene modifiers do?

Answer 10

Block production of leukotrienes

Question 11

Are leukotriene modifiers long-term controllers or short-acting treatments?

Answer 11

Long-term

Question 12

Are mast cell stabilizers long-term controllers or short-acting treatments?

Answer 12

Long-term

Question 13

What do methylxanthines do?

Answer 13

Bronchodilatin through inhibition of PDE III and PDE IV

Question 14

Are methylxanthines long-term controllers or short-acting treatments?

Answer 14

Both

Question 15

What do anti-IgE medications do?

Answer 15

Inhibit IgE binding to receptors on mast cells and basophils, inhibit mediator release and attenuation of early and late-phase allergic response

Question 16

Are anti-IgE medications long-term controllers or short-acting treatments?

Answer 16

Long-term

Question 17

What do phosphodiesterase-4 inhibitors do?

Answer 17

Inhibit PDE4 leading to an increase in cAMP

Question 18

Are phosphodiesterase-4 inhibitors long-term controllers or short-acting treatments?

Answer 18

Long-term

Question 19

What do Inhaled short acting beta2 agonists do?

Answer 19

Increase cAMP and antagonize bronchoconstriction which leads to smooth muscle relaxation (reverses obstruction and improve airflow)

Question 20

What do short-acting anticholinergics do?

Answer 20

Competitively inhibit cholinergic receptors in bronchial smooth muscle which leads to a decrease in cGMP and bronchodilation

Question 21

What do systemic corticosteroids do?

Answer 21

Decrease inflammation and increase response to beta2 agonists