PHRM 825: NSAIDs and DMARDs

Question 1

What are the mild and more common side effects of NSAIDs?

Answer 1

Dyspepsia, nausea, vomiting

Question 2

What are the more severe and rare side effects of NSAIDs?

Answer 2

Blood loss, ulcer, GI hemorrhage

Question 3

What is the only NSAID that irreversibly inhibits COX by acetylating a serine residue in the active site?

Answer 3

Aspirin

Question 4

10% of asthmatics are hypersensitive to what med?

Answer 4

Aspirin

Question 5

What is Reye’s syndrome and when does it occur?

Answer 5

• Rare, life-threatening condition characterized by vomiting, delirium, and coma
• Occurs in children who have had the flu or chicken pox

Question 6

What population is aspirin contraindicated?

Answer 6

Anyone under 12 who has had a fever

Question 7

What drugs can NSAIDs interact with?

Answer 7

Drugs that are highly bound to serum albumin binding sites

Question 8

What NSAID does not cause GI bleeding?

Answer 8

Salsalate (Disalcid)

Question 9

What NSAID is widely accepted as an alternative to narcotic analgesics?

Answer 9

Ketorolac

Question 10

What are the 2 non-carboxylate drugs?

Answer 10

Nabumetone and Meloxicam

Question 11

What is the only “Selective COX-2 inhibitor” still on the US market?

Answer 11

Celecoxib

Question 12

What is the common underlying mechanism of action for DMARDs?

Answer 12

Immunosuppression of the autoimmune response

Question 13

Why is methotrexate contraindicated in pregnancy?

Answer 13

It is a folic acid antagonist