Pharmacology of Antiretrovirals Flashcards
What drug class should be added to 2NRT therapy for naive patients with no resistance
Intergrase inhibitors
What is in Biktarvy
Bictegravir, emtricitabine, TAF
What is in Triumeq
Abacavir, Dolutegravir, Lamivudine
What is in Descovy, Truvada
TAF and emtricitabine, TDF and emtricitabine
What isentress/isentress HD, what drugs should it be mixed with, what is the other integrase inhibitor that can be combined with previous regimen
Raltegravir/ Descovy or Truvada/ Dolutegravir (Tivicay)
What are the components released when a viral cell mixes with its target, what are the proteins released
2 viral RNA strands and 3 essential proteins, Intergrase, protease, reverse transcriptase
What does intergrase do, viral protease
integrate viral dsDNA into the host DNA, cut viral proteins to make new viral proteins
What does post exposure prophylaxis due, when does it work best
Prevent viral DNA from intergrating into host dNA, within 3 days
T/F: Single tablet regimens may not be ideal for patients with low renal clearance
True
What should class of medications should be separated by 2 hours if using a intergrase inhibitor
Antacids
Which one dose daily regimen tablet is first line for naive patients and should only be used if CrCl is greater than 30ml/min and can be taken with or without food
Biktarvy
What are side ffects of using biBiktarvy
diarrhea, nausea, fatigue, insomnia, dizziness, headache
What are the liver enzymes that are contraindicated with Biktarvy use
Cyp3a4, UGTa1a, Oct2, MaTE1
What is the single tablet regimen that can be taken with or without food and REQUIRES a HLA-B*5701 test before use, what component causes this test to be essential
Triumeq, Abacavir
What is the two tablet regimen that can be given but must be seperated by at 2 hours before antacids or 6 hours after antacids
Dolutegravir (tivicay) PLUS Desovy (TAF/emtricitabine) or Truvada (TDF/emtricitabine)
What other integrase inhibtor can mixed with Descovy or Truvada, what is a significant side effect
Isentress (raltegravir), Rhabdomyosis
What drug is considered truly effective and is Stribild 2.0, what is in it, what does the CrCl have to be
Genvoya/ elivitegravir, covicistat, TAF, emtricitabine, greater than 30 ml/min
T/F: Genvoya can be taken with or without food
False: Genvoya MUST be taken with food
What polyvalent cations should be avoided when taking integrase inhibitors
Calcium and iron
What is a usually booster given for protease inhibitors
Cobistat or ritonovir
What is the only single tablet protease inhbitor combination that should not be taken with CrCl less than 30 ml/min and severe hepatic impariment
Symtuza
T/F: All protease inhibitors should be monitored for hepatic inhibition
True
T/F: Simvastatin should not be taken if somone is taking HIV medication
True
