Pharmacology of Antiretrovirals

Question 1

What drug class should be added to 2NRT therapy for naive patients with no resistance

Answer 1

Intergrase inhibitors

Question 2

What is in Biktarvy

Answer 2

Bictegravir, emtricitabine, TAF

Question 3

What is in Triumeq

Answer 3

Abacavir, Dolutegravir, Lamivudine

Question 4

What is in Descovy, Truvada

Answer 4

TAF and emtricitabine, TDF and emtricitabine

Question 5

What isentress/isentress HD, what drugs should it be mixed with, what is the other integrase inhibitor that can be combined with previous regimen

Answer 5

Raltegravir/ Descovy or Truvada/ Dolutegravir (Tivicay)

Question 6

What are the components released when a viral cell mixes with its target, what are the proteins released

Answer 6

2 viral RNA strands and 3 essential proteins, Intergrase, protease, reverse transcriptase

Question 7

What does intergrase do, viral protease

Answer 7

integrate viral dsDNA into the host DNA, cut viral proteins to make new viral proteins

Question 8

What does post exposure prophylaxis due, when does it work best

Answer 8

Prevent viral DNA from intergrating into host dNA, within 3 days

Question 9

T/F: Single tablet regimens may not be ideal for patients with low renal clearance

Answer 9

True

Question 10

What should class of medications should be separated by 2 hours if using a intergrase inhibitor

Answer 10

Antacids

Question 11

Which one dose daily regimen tablet is first line for naive patients and should only be used if CrCl is greater than 30ml/min and can be taken with or without food

Answer 11

Biktarvy

Question 12

What are side ffects of using biBiktarvy

Answer 12

diarrhea, nausea, fatigue, insomnia, dizziness, headache

Question 13

What are the liver enzymes that are contraindicated with Biktarvy use

Answer 13

Cyp3a4, UGTa1a, Oct2, MaTE1

Question 14

What is the single tablet regimen that can be taken with or without food and REQUIRES a HLA-B*5701 test before use, what component causes this test to be essential

Answer 14

Triumeq, Abacavir

Question 15

What is the two tablet regimen that can be given but must be seperated by at 2 hours before antacids or 6 hours after antacids

Answer 15

Dolutegravir (tivicay) PLUS Desovy (TAF/emtricitabine) or Truvada (TDF/emtricitabine)

Question 16

What other integrase inhibtor can mixed with Descovy or Truvada, what is a significant side effect

Answer 16

Isentress (raltegravir), Rhabdomyosis

Question 17

What drug is considered truly effective and is Stribild 2.0, what is in it, what does the CrCl have to be

Answer 17

Genvoya/ elivitegravir, covicistat, TAF, emtricitabine, greater than 30 ml/min

Question 18

T/F: Genvoya can be taken with or without food

Answer 18

False: Genvoya MUST be taken with food

Question 19

What polyvalent cations should be avoided when taking integrase inhibitors

Answer 19

Calcium and iron

Question 20

What is a usually booster given for protease inhibitors

Answer 20

Cobistat or ritonovir

Question 21

What is the only single tablet protease inhbitor combination that should not be taken with CrCl less than 30 ml/min and severe hepatic impariment

Answer 21

Symtuza

Question 22

T/F: All protease inhibitors should be monitored for hepatic inhibition

Answer 22

True

Question 23

T/F: Simvastatin should not be taken if somone is taking HIV medication

Answer 23

True