Pharmacology of Antiretrovirals 2 Flashcards
What are the three entry inhibitors for HIV
Ibalizumab, Maraviroc, Enfurvitide
Which entry inhibitor block at the CD-4 receptor and is indicated in multidrug resistant HIV-1 infection failing their current regimen
Ibalizumab
T/F: All entry inhibitors should only be indicated in HIV resistance and should not be taken alone
True
What entry inhibitor binds to CCR4 receptor and is available as a tablet while also requiring a Tropism test
Maraviroc
What drug interactions should be anticipated for when using maraviroc, what are adverse effects
CYP3A4, hepatotoxicity, dizziness, postural hypotension
What entry inhibitor must be reconstituted, kept refrigerated and keeps HIV cells from dumping their gentic material inside the cell directly
Enfuvirtide
T/F: Enfuvirtide has an injection site reaction 98% of the time
True
What nucleoside is not renally dosed like the rest
Abacavir
T/F: All proteaste inhibitors need to be boosted
True
What steroid inhaler must be avoided protease inhibitors and NNRTs
Fluticasone
What class of antiretrovials are is cautionded in pregnant women due to neural tube defects, what should be done about them
Intergrase inhibitor, should not be started during the first trimester but if the patient is already on the medication they can stay on it and monitored closely
T/F: Intergrase inhibitors can cause weight gain and should not be given concurrently with antacids
True
What viral load is considered undectable
Less than 1000
What is the difference between PrEP and PEP
Prep is pre exposure prophylaxis used for people have unsafe sex or needle use with HIV patients, PEP is post exposure prophylaxis for patients like healthcare workers who may have been exposed
What is the only drug approved for Prep and Hep B
Truvada
