Antibiotics: Protein synthesis

Question 1

What MOA for antibiotics is the most common and is arguably the most important

Answer 1

Inhibitors of protein synthesis

Question 2

T/F: The ribosome is made up of two subunits, the large subunit and the small subunit

Answer 2

True

Question 3

What does a ribosome hold in place in order to use genetic code to make proteint

Answer 3

mRNA (messenger RNA)

Question 4

What binds to the codon of mRNA that is held within a ribosome

Answer 4

The anticodon of tRNA

Question 5

Out of the three sites on a ribosome which site allows for a tRNA to enter and match with a mRNA

Answer 5

The A site

Question 6

Out of the three sites of a ribosome where is the enzymatic portion of the ribosome that catalyzes peptide bond formation

Answer 6

The P site

Question 7

Out of the three sites of a ribosome where is the site that allows tRNA that have lost their amino acid to exit

Answer 7

The E site

Question 8

What is the function of the large ribosomal subunit, What is the function of the small ribosomal subunit

Answer 8

Polymerization of amino acids into polypeptides, selection of tRNA according to mRNA codons

Question 9

T/F: Antibiotics that bind to the large ribosomal subunit interfere with tRNA binding or the accuracy of protein synthesis

Answer 9

False: Antibiotics that bind to the large ribosomal subunit interfere with tRNA binding or the accuracy of protein synthesis

Question 10

What is the main component of ribosomes

Answer 10

rRNA (ribosomal RNA)

Question 11

Why is the ribosome an evolutionary preferred antibiotic target

Answer 11

There are several identical genes in genomes of bacteria code for rRNA