Antibiotics: Protein synthesis Flashcards
What MOA for antibiotics is the most common and is arguably the most important
Inhibitors of protein synthesis
T/F: The ribosome is made up of two subunits, the large subunit and the small subunit
True
What does a ribosome hold in place in order to use genetic code to make proteint
mRNA (messenger RNA)
What binds to the codon of mRNA that is held within a ribosome
The anticodon of tRNA
Out of the three sites on a ribosome which site allows for a tRNA to enter and match with a mRNA
The A site
Out of the three sites of a ribosome where is the enzymatic portion of the ribosome that catalyzes peptide bond formation
The P site
Out of the three sites of a ribosome where is the site that allows tRNA that have lost their amino acid to exit
The E site
What is the function of the large ribosomal subunit, What is the function of the small ribosomal subunit
Polymerization of amino acids into polypeptides, selection of tRNA according to mRNA codons
T/F: Antibiotics that bind to the large ribosomal subunit interfere with tRNA binding or the accuracy of protein synthesis
False: Antibiotics that bind to the large ribosomal subunit interfere with tRNA binding or the accuracy of protein synthesis
What is the main component of ribosomes
rRNA (ribosomal RNA)
Why is the ribosome an evolutionary preferred antibiotic target
There are several identical genes in genomes of bacteria code for rRNA
