Pharmacology ANS Sept29 A1

Question 1

Adrenal medula in ANS view

Answer 1

postganglionic neuron with no axon that simply secretes E and NE

Question 2

SS and PSS receptors

Answer 2

SS: adrenergic (alpha beta)
PSS: nicotinic (pregang), muscarinic (postgang)

Question 3

autoreceptor (presynaptic receptor) vs heteroreceptor

Answer 3

auto: sensitive to neuron’s hormone or nrt
hetero: sensitive to other neuron(s) hormone or nrt

Question 4

targets of synapse (cholinergic junction for example) (4)

Answer 4

pre and post synaptic receptors
AchE
vesicle release mechanism

Question 5

muscarinic vs nicotinir Ach receptors

Answer 5

muscarinic: activated by muscarine
nicotinic: activated by nicotine

Question 6

locations (give 3) of nicotinic AChRs and why diff effects to nicotine

Answer 6

brain, skeletal muscle, ganglion

Unrelated effects bc diff affinities to nicotine

Question 7

Families of AchE and 2 uses

Answer 7

Short and long actin

Nerve gas vs therapeutic (similar to muscarinic agonists)

Question 8

mAchR how it works and example of location

Answer 8

metabotropic receptor-G protein- K+ channel opening -K+ efflux-hyperpolarization

sinoatrial node of heart

Question 9

mAchR time to action

Answer 9

seconds to minutes

Question 10

nAchR how it works

Answer 10

ligang (Ach) gated. conform change allowing Na influx, depol

Question 11

nAchR time to action

Answer 11

milliseconds

Question 12

where drugs can act at adrenergic junction (6)

Answer 12

• pre and post syn R
• ntr synthesis
• ntr storage
• ntr release
• ntr reputake
• enzymatic inactivation

Question 13

reuptake at cholinergic vs adrenergic junction

Answer 13

Ach broken down, choline reuptake

NE transporter

Question 14

types of presynaptic receptors

Answer 14

autoreceptors or heteroreceptors

Question 15

autoreceptors location and use

Answer 15

presynaptic
negative feedback (inhibit ntr release)

Question 16

mAchRs types and locations

Answer 16

M1: brain and postgang neurons
M2: autoreceptors and heart
M3: airways, exocrine glands

Question 17

nAchRs locations

Answer 17

NMJ (not autonomic ganglia)
pregang neurons
brain

Question 18

alpha adrenergic receptors types and locations

Answer 18

alpha1: vascular SM
alpha2: autoreceptors

Question 19

beta adrenergic receptors types and locations

Answer 19

beta1: heart
beta2: bronchi

Question 20

PSS effect on blood flow to skin, viscera and muscle

Answer 20

no effect

Question 21

SS control of heart

Answer 21

NE (SS) and E (circulating)

Question 22

PSS main nerve origin

Answer 22

cranial nerve X: vagus

Question 23

SS: how affects blood flow

Answer 23

SM constriction in skin and viscera

SM relaxation in skeletal muscle

Question 24

What regulates MAP (BP)

Answer 24

PVR and CO (HR and SV)

Question 25

ANS BP regulation

Answer 25

Baroreceptors detect MAP and send info to vasomotor center which sends info to PSS and SS

Question 26

what SS and PSS do when receive info from vasomotor center for BP regul

Answer 26

SS: increase HR, SV, PVR, venous tone
PSS: decrease HR (VAGUS)

Question 27

nerve and receptor of PSS acting on heart and where

Answer 27

Vagus, PSS, M2 mAChR, sinoatrial node

Question 28

SS action to increase BP that is hormonal

Answer 28

increase renin secretion at kidneys

Question 29

how SS acts on bronchi

Answer 29

circulating E, B2 adrenergic receptors on SM

Question 30

E acts on which receptors

Answer 30

all adrenergic rece

Question 31

NE acts on which receptors

Answer 31

alpha 1, alpha 2, beta 1

Question 32

beta 2 receptors give 2 locations

Answer 32

SM of bronchi

SM of skeletal muscle arteries