Pharmacology ANS Sept29 A1 Flashcards
Adrenal medula in ANS view
postganglionic neuron with no axon that simply secretes E and NE
SS and PSS receptors
SS: adrenergic (alpha beta)
PSS: nicotinic (pregang), muscarinic (postgang)
autoreceptor (presynaptic receptor) vs heteroreceptor
auto: sensitive to neuron’s hormone or nrt
hetero: sensitive to other neuron(s) hormone or nrt
targets of synapse (cholinergic junction for example) (4)
pre and post synaptic receptors
AchE
vesicle release mechanism
muscarinic vs nicotinir Ach receptors
muscarinic: activated by muscarine
nicotinic: activated by nicotine
locations (give 3) of nicotinic AChRs and why diff effects to nicotine
brain, skeletal muscle, ganglion
Unrelated effects bc diff affinities to nicotine
Families of AchE and 2 uses
Short and long actin
Nerve gas vs therapeutic (similar to muscarinic agonists)
mAchR how it works and example of location
metabotropic receptor-G protein- K+ channel opening -K+ efflux-hyperpolarization
sinoatrial node of heart
mAchR time to action
seconds to minutes
nAchR how it works
ligang (Ach) gated. conform change allowing Na influx, depol
nAchR time to action
milliseconds
where drugs can act at adrenergic junction (6)
- pre and post syn R
- ntr synthesis
- ntr storage
- ntr release
- ntr reputake
- enzymatic inactivation
reuptake at cholinergic vs adrenergic junction
Ach broken down, choline reuptake
NE transporter
types of presynaptic receptors
autoreceptors or heteroreceptors
autoreceptors location and use
presynaptic negative feedback (inhibit ntr release)
mAchRs types and locations
M1: brain and postgang neurons
M2: autoreceptors and heart
M3: airways, exocrine glands
nAchRs locations
NMJ (not autonomic ganglia)
pregang neurons
brain
alpha adrenergic receptors types and locations
alpha1: vascular SM
alpha2: autoreceptors
beta adrenergic receptors types and locations
beta1: heart
beta2: bronchi
PSS effect on blood flow to skin, viscera and muscle
no effect
SS control of heart
NE (SS) and E (circulating)
PSS main nerve origin
cranial nerve X: vagus
SS: how affects blood flow
SM constriction in skin and viscera
SM relaxation in skeletal muscle
What regulates MAP (BP)
PVR and CO (HR and SV)
ANS BP regulation
Baroreceptors detect MAP and send info to vasomotor center which sends info to PSS and SS
what SS and PSS do when receive info from vasomotor center for BP regul
SS: increase HR, SV, PVR, venous tone
PSS: decrease HR (VAGUS)
nerve and receptor of PSS acting on heart and where
Vagus, PSS, M2 mAChR, sinoatrial node
SS action to increase BP that is hormonal
increase renin secretion at kidneys
how SS acts on bronchi
circulating E, B2 adrenergic receptors on SM
E acts on which receptors
all adrenergic rece
NE acts on which receptors
alpha 1, alpha 2, beta 1
beta 2 receptors give 2 locations
SM of bronchi
SM of skeletal muscle arteries
