Cytogenetics Oct12 M3 Flashcards
morphologic groups of chromosomes
metacentric, submetacentric, acrocentric
molecule holding chromosomes until anaphase
cohesins
name of structure on chromosomes that the mitotic spindle attaches to
kinetochores
important proteins in kinetochore
CENP proteins
2 important chromosome regions
centromere, telomere
telomere function and how
protect DNA from ligation and degradation. form loop. tell cell not a broken piece of DNA
how telomere changes with time
shortens with cell divisions
name of the phases in meiosis 1
leptotene, zygotene, early pachytene, late pachytene, diplotene, diakinesis
when crossing over occurs at meiosis 1
pachytene stage (early and late)
name of crossing over structure inmeiosis
chiasma
non-disjunction 3 types
2 homologous chromosomes
2 sister chromatids
how mosaicism can happen from non disjunction
if non disjunction at mitosis
constitutional mosaicism def
at least 2 cell lines with diff chromosomal complements in a fetoplacental unit derived from a single zygote
chimerism def
diff cell lines in diff zygotes
common disease where mosaicism taking place
cancer