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Bloc B - Respiration > Histology I Oct4 M1 > Flashcards

Histology I Oct4 M1 Flashcards

1
Q

general plan of resp system

A
  • mucosa (epith layer + LP)
  • submucosa (muscle, glands, cartilage)
  • aventitia
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2
Q

lamina propria characteristics

A

loose CT, cellular, few fibers, some elastic fibers

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3
Q

submucosa characteristics

A

dense irregular CT, more fibers, collagen

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4
Q

adventitia characteristics and function

A

dense irregular CT. connects with adventitia of other organs around

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5
Q

epithelium name and charac in resp

A

respiratory epith.

  • pseudostratified columnar ciliated
  • goblet cells
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6
Q

what portion of resp conducting system contain a lot of elastic fibers in submucosa

A

trachea, bronchi, bronchioles

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7
Q

two types of cartilage and location

A

elastic (larynx), hyaline (nasal septum, trachea and downwards)

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8
Q

serous vs mucous gland histo

A

mucous don’t stain well on H and E bc lot of glycoprot

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9
Q

5 cell type in resp epith.

A
  • ciliated cells
  • goblet cells
  • brush cells
  • small granule cell or argentaffin cell or DNES cells
  • short cells
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10
Q

brush cells charact

A

only on EM. might be sensory

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11
Q

argentaffin cells charact

A

contain granules, only silver nitrate stain, secrete serotonin and epinephrine basally to regul capillaries in LP

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12
Q

short cells charact

A

stem cells, cause of problems in trchea and bronchi

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13
Q

resp epith lower vs upper nuclei rows

A

upper row: ciliated, goblet cells, brush cells

lower row: argentaffin and short cells

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14
Q

cilia axoneme structure

A

nine pairs of mtbs + central pair

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15
Q

axoneme peripheral mtb pairs vs central pair

A

peripheral: 10 + 13 filaments form mtb
central: 13 + 13 filaments form mtb

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16
Q

proteins in axoneme and consequence of mutations

A

dynein arms, nexins, radial spokes, inner sheaths

mutation: IMMOTILE SYNDROME

17
Q

dynein arms: what

A

attach to complete mtbs on periphery of axoneme (provide motility)

18
Q

nexin: what

A

attaches 2 peripheral mtb pairs

19
Q

radial spoke: what

A

attaches peripheral pairs of mtbs to central sheath

20
Q

basic monomer of mtbs

A

tubulin (alpha and beta, 2 dif genes)

21
Q

structure at base of cilia and charact

A

basal bodies. no central mtbs. 9 peripheral triplets of mtbs. inner and middle mtb continuous with axoneme. 3rd stops at plasma membrane

22
Q

symptoms of primary ciliary diskenesia (dynein mutaiton)

A

infertility (sperm cilia),

situs invertus, chronic sinusitis, bronchiectasis

23
Q

cilia in sperm

A

9 peripheral mtb pairs and one central pair

24
Q

goblet cell charact + on histo

A

lot of granules, extensive golgi, glycoprotein vesicles (granules). stain bad

25
Q

CF pathophysiology resp

A

mutation in CFTR (choride channel) doesn’t translocate at membrane, GOBLET CELL doesn’t pump fluid. rigid mucous, bronchiectasis

26
Q

CF affects what other organs and how

A

pancreas, reprod system (vas deferens closed)

27
Q

where olfactory epithelium found

A

nasal cavity, upper conchae to floor of ethmoid bone

28
Q

nasal septum location and composition

A

middle of nasal cavities (separates it in two). HYALINE CARTILAGE

29
Q

olfactory epithelium: what cell type absent

A

goblet cells

30
Q

olfactory epith: 3 cell types

A
  • columnar cells or sustentacular cells
  • modified neurons
  • basal cells
31
Q

olfact epith: upper vs lower nuclei rows

A

upper: columnar or sust cells
lower: neurons, basal cells

32
Q

olf epith: columnar cells charact

A

microvilli. granules like in goblet cells.

33
Q

olf epith: neurons portions (5)

A

body, dendrite, bulb, cilia, axon

34
Q

olf epith: neuron’s bulb and cilia charact

A
  • bulb has 6 to 8 olfact cilia

- cilia has 9 periph mtb pairs + 2 central

35
Q

olf epith: neuron’s axon charac

A

unmyelinated, surrounded by Schwann cells, joins other axons to form fila olfactoria (unmyel nerve in LP)

36
Q

olf epith: basal cell charac

A

embrases neuron shape. some are stem cells

37
Q

LP below olfact epith (2 charact)

A
  • Bowmann’s glands (serous glands, stain well)

- fila olfactoria

38
Q

resp epith location in nasal cavity

A

lower part

39
Q

LP below resp epith of nasal cavity: 2 things to note

A
  • serous glands

- some glands in submucosa too

Bloc B - Respiration (36 decks)

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