Pharmacology

Question 1

Binding affinity

Answer 1

Degree of chemical attraction between ligand and receptor

Question 2

Efficacy

Answer 2

Ability of a bound ligand to activate receptor

Question 3

Dose-Response Curve

Answer 3

Graph that shows relationship between drug dose and effects

Question 4

Bioavailability

Answer 4

Amount of drug that is free to act on target

Varies with route of administration

Question 5

Bio transformation

Answer 5

Produces active metabolites that may produce side effects

Question 6

Metabolic tolerance

Answer 6

Organ systems become more effective at eliminating the drug

Question 7

Functional tolerance

Answer 7

Change in number of receptors

Down regulation of agonists

Up regulation of antagonists

Question 8

Cross-tolerance

Answer 8

Tolerance for one drug is generalized to other drugs in its class

Question 9

Presynaptic drugs

Answer 9

3 effects on neurotransmitters

1) production
2) release
3) clearance

Question 10

Postsynaptic Drugs

Answer 10

Work as agonists or antagonist

Question 11

ED50

Answer 11

Effective dose: when drug has an effective response in 50% of individuals

Question 12

TD50

Answer 12

Toxic dose: when adverse side effects arise in 50% of people

Question 13

LD50

Answer 13

Lethal dose: dose of drug required to kill 50% of individuals