Pharmacology Flashcards
why should women avoid NSAIDs in late pregnancy
it closes the ductus arteriosus
why should St John’s Wort be avoided
interacts with drugs
in A+E/AMU, what should always be done in women of child bearing age before giving a medication
pregnancy test
what doses of folic acid should women be on if they are trying to conceive
400 ug - normally
5mg - NTD, DM, AEDs, obese
list some teratogenic drugs
ACEI/ARBs warfarin lithium Na valproate phenytoin methotrexate retinoids tetracyclines alcohol sulphonylureas
which drugs should be avoided in late pregnancy
NSAIDs
warfarin
opiates
B blockers
is insulin safe in pregnancy
yes
what medications are safe to treat hypertension in pregnancy
labetolol
methyldopa
nifedipine
management of UTI/asymptomatic bacteriuria in pregnancy
1st/2nd trimester - nitrofurantoin
3rd trimester - trimethoprim
which drugs should not be used if breast feeding
lithium BZDs phenobarbitone amiodarone cytotoxics bromocriptane
which pregnant women should take daily aspirin
PET
DM
Red pathway
APLS
where are B12 and intrinsic factor absorbed
ileum
where is Vit D absorbed
interstines
where is folate absorbed
duodenum
jejunum
where is Fe absorbed
Duodenum
when is anti-D given to pregnant women
28 and 34 weeks
what are sensitising events in terms of Rh disease
miscarriage >12 weeks abdominal trauma birth TOP ectopic pregnancy placental abruption foetal death external cephalic version
what happens if you dont give anti-D to a Rh- woman
anti-Rh antibodies will attack the baby’s RBC and cause haemolytic anaemia and cause high levels of bilirubin which is harmful
what is AFP
Alpha feto protein
produced by embryonic yolk sac and foetal liver
what is a Kleihauer yest
tests for mixing of maternal and foetal blood to see if more anti-D is required
which anti-emetic is safe to use in pregnancy
cyclizine
how do you treat UTI’s/asymptomatic bacteriuria in pregnancy
1st + 2nd trimester - nitrofurantoin
3rd trimester - trimethoprim
