Embryology Flashcards

1
Q

What is gastrulation

A

Formation of the germ layers: endoderm, mesoderm and ectoderm

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2
Q

What are the divisions of the mesoderm

A

Paraxial
Intermediate
Lateral plate

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3
Q

Which mesoderm division forms the urogenital system

A

intermediate mesoderm

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4
Q

At what week of gestation does sexual differentiation occur

A

week 7

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5
Q

Where do primordial germ cells come from (PGCs)

A

yolk sac and go into the developing gonads

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6
Q

what are somatic support cells

A

formed from proliferating epithelium that envelop the PGCs

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7
Q

what are the types of genital ducts formed

A

Mesonephric/Wollfian duct

Paramesonephric/Mullerian duct

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8
Q

The mesonephric/wollfian duct develops in females, true or false

A

FALSE

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9
Q

The paramesonephric/mullerian duct develops in females, true or false

A

TRUE

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10
Q

Which protein triggers development of male development

A

SRY male transcription factor from presence of Y chromosome

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11
Q

In males, what do somatic support cells become

A

Sertoli cells

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12
Q

What do sertoli cells do

A

secrete AMH

stimulate Leydig cells which release testosterone

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13
Q

What is AMH and what is its function

A

Anti Mullerian Hormone

causes regression of paramesonephric/Mullerian duct

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14
Q

What does testosterone induce the formation of

A

Vas deferens, epididymis, seminal vesicles

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15
Q

What does DHT induce the formation of

A

Male external genitalia and prostate

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16
Q

What is the embryology of the testes and how do they descend

A

Testes originate at posterior abdominal wall ~T10 level

By birth, they have descended into the scrotum by the pull of the gubernaculum

17
Q

What is failure of testes descent called

A

Cryptorchidism

18
Q

What happens in the absence of SRY protein and absence of the Y chromosome

A

Female development occurs

19
Q

In females, what do somatic support cells become

A

granulosa cells

20
Q

What are thecal cells

A

Equivalent to Leydig cells in males

21
Q

what is the embryological origin of the superior 1/3rd of the vagina

A

endoderm

22
Q

What is the embryological origin of the inferior 2/3rds of the vagina

A

mesoderm

23
Q

What is the embryological origin of the glans penis

A

ectoderm

24
Q

What is the embryological origin of the penis itself

A

endoderm