Pharmacology Flashcards
What is the method of action for prazosin?
Alpha 1 antagonist
What are the common side effects of prazosin in cats?
Hypotension
Lethargy
GI upset
Ptyalism
What is the method of action of levetiracetam?
Modulating voltage-gated calcium-dependent neurotransmitter release
Multi-drug resistance is when bacteria are resistant to….
1 agent in > or = 3 separate anti microbial categories
The duration of local anaesthetic action is primarily determined by
Protein binding
Local anaesthetic potency is primarily determined by
Lipid solubility
How does LMWH work?
Binds to and accelerates antithrombin III to inhibit factor Xa and thrombin
Opioids given parenterally avoids which mechanism of metabolism of opioids?
First pass metabolism by the liver
Which G proteins are linked to each adrenergic receptor
Alpha 1 Gq
Alpha 2 Gi
Beta 1 Gs
Beta 2 Gs
Noradrenaline method of action
Works on alpha 1 and 2
With also some beta 1
Results in vasoconstriction and increase in BP
Increases cellular Ca2+ by IP3 and DAG
Adrenaline method of action
Potent beta 1and 2 and alpha 1 and 2 receptor agonist
Phenylephrine
Potent alpha 1 and alpha 2 receptor agonist
(No beta agonist activity)
Dobutamine method of action
Mostly beta 1 (but also beta 2 and alpha 1 and alpha 2)
How does gabapentin work?
Binds to alpha 2 delta 1 subunit of voltage gated calcium channel
Decreases presynaptic influx of calcium
Decreases release of excitatory neurotransmitters from presynaptic membranes
How is gabapentin absorbed
Absorbed from GI tract via L-amino transport system
Saturable
Disproportionate nonlinear pharmacokinetics and gabapentin serum concentration that doesn’t increase linearly with drug dose
