Cardiovascular Drugs MOA

Question 1

Method of action of digoxin

Answer 1

Vagomimetic- slows conduction AV node and increases vagal tone in ventricles

Increases availability of intracellular Ca2+ and decrease Na/K ATPase activity in cardiomyocyte

Question 2

What class of drug is digoxin?

Answer 2

Cardiac glycoside (class 5)

Question 3

What class of drug is esmolol?

Answer 3

Selective Beta 1 blocker (class II)

Question 4

What class of drug is lidocaine?

Answer 4

Sodium channel blocker (class Ib)

Question 5

Name two side effects of esmolol?

Answer 5

Hypotension
Bradycardia

Question 6

Method of action of diltiazem?

Answer 6

Calcium channel blocker
Non dihydropyridine
Slows conduction through the AV node
Prolongs PQ interval
Prolongs refractory time
Weak negative inotrope effects

Question 7

Esmolol method of action

Answer 7

Class II antiarrhythmic drug (beta blocker)

Blocks beta 1 adrenergic receptors in myocardium

Question 8

Method of action procainamide

Answer 8

Class Ia binds and inhibits fast sodium channels

Question 9

Name two drugs that can be used to manage supraventricular tachyarrhythmias?

Answer 9

Atenolol (selective b1 blocker) and propranolol (non-selective b1,b2)

Question 10

What receptors does vasopressin act on?

Answer 10

V1 receptor on vascular smooth
Muscle

Question 11

Under what circumstances do arterial clots form?

Answer 11

High shear force
Endothelial damage
Platelet rich, fibrin poor
Antiplatelet therapy

Question 12

Under what circumstances do venous blood clots form

Answer 12

Low shear conditions
Fibrin and RBC rich, platelet poor
Platelet number less focussed on platelet number and function
Anticoagulant therapy

Question 13

Under what circumstances do venous clots form

Answer 13

Low shear
Fibrin and rbcs rich, platelet poor
Formation less dependent on plt number and function
Anticoagulant therapy