Coagulation Flashcards
Cytokines in systemic inflammation trigger coagulation through the binding of which coagulation factor?
Factor VII
Name the stages of cell based coagulation
Initiation
Amplification
Propagation
Name the stages of primary haemostasis/platelet plug
- Platelet adhesion
- Platelet activation
- Platelet aggregation
What do dense platelet granules contain
ADP
ATP
5-HT
Ca2+
Pyrophosphate
What do alpha platelet granules contain?
Fibrinogen
VFW
Fibronectin
PF4
Thrombospondin
PDGF
Factor V
PAI-1
Alpha 2-antiplasmin
Warfarin method of action
Inhibits vitamin K epoxide reductase leading to vitamin K levels decreasing and affecting vitamin K factors
Aspirin method of action
Irreversible inhibition of COX and conversion of archidonic acid to thromboxane A2
Clopidogrel method of action
Irreversible P2Y12 receptor inhibitor
Vitamin K dependent coagulation factors
Factors 2,7,9,10
What does frozen plasma contain and what are the indications of use? As per SACCM 2023
Contain coag factors
-gradual loss of FVIII and FX
-albumin
-other proteins
Used for coagulopathies and hypoalbuminaemia
What does CT stand for on a VCM?
Time from test initiation until amplitude of 1% is achieved (minutes)
What does CFT stand for in a VCM?
Clot formation time
Time between the 1% amplitude and 10% amplitude of the clotting signal (minutes)
What does alpha angle mean on a VCM?
The angle between the middle axis and the tangent to the clotting curve through the 1% amplitude point (degrees)
What does the MCF mean on a VCM?
Maximum clot firmness
Maximum amplitude of the VCM graph (VCM units)
What does LI30 stand for
Lysis index at 30 mins
Fibrinolysis 30 minutes after clotting time; measured as the relation of the amplitude to the maximum clot firmness (%remaining clot firmness)
