Immunology

Question 1

Name 10 DAMPs

Answer 1

Herparan sulfate
Fibrinogen
Heat shock proteins
ATP
Defensins
Syndecans
Mitochondrial DNA
RNA
Histones
Mitochondrial ROS

Question 2

Name 5 acute phase proteins

Answer 2

CRP-opsonisation
Procalcitonin-iNOS
Fibrinogen- coagulation
Ferritin- binds iron so decreases microorganism iron availability
Haptoglobin-binds HGB
Mannan binding lectin- complement activation
Complement- opsonisation, chemotaxis, lysis
Serum amyloid A- chemotaxis, extracellular marrix degradation

Question 3

List 5 actions of complement

Answer 3

Chemotaxis
Increase cytokine levels
Increase TF expression
Increased vascular
Permeability
Opsonisation

Question 4

Which complement molecules account for most actions of complement

Answer 4

C3a and C5a

Question 5

Name 3 negative acute phase proteins

Answer 5

Retinol binding protein
Albumin
Cortisol binding globulin (CBG)
Transferrin
Transcortin
Antithrombin
Transthyretin

Question 6

Name 5 pro-inflammatory cytokines

Answer 6

TNF alpha
IL1
IL6
IL8 (CXCL8)
IL12
Bradykinin
PAF
IFN gamma

Question 7

Name 4 different classes of pattern recognition receptors

Answer 7

•Toll like receptors (TLRs)
•Nod like receptors (NLRs)
•RIG-I-like receptors (RLRs)
•C type lectin receptors (CLRs)

Question 9

What makes up the full SOFA score?

Answer 9

Respiratory PaO2
Mentation (Glasgow Coma Score)
Hepatic- Serum bilirubin
Renal-Creatinine
Coagulation-Platelets
Cardiovascular-Hypotension

Question 10

What makes up the quick sofa score

Answer 10

Hypotension (<100mmhg SBP)
Altered mentation
Tachypnoea