Pharmacology

Question 1

what affects pharmacokinetics in pregnancy?

Answer 1

absorption affect by morning sickness
volume of distribution increases in 2nd trimester
increased liver and renal excretion
hypotension in 2nd trimester

Question 2

why should you avoid tetracyclines in pregnancy?

Answer 2

grey teeth in pregnancy and those <12

Question 3

what is phenytoin associated with in pregnancy?

Answer 3

cleft lip and palate

Question 4

what is valproate associated with in pregnancy?

Answer 4

spina bifida

anencephaly

Question 5

management of hyperemesis gravidarum/ vomiting in pregnancy

Answer 5

anti emetics and fluids
steroids
folic acid + thiamine
LMWHs

Question 6

anti-emetic choice in pregnancy?

Answer 6

cyclizine or prochlorperazine
2nd line= metoclopramide
(ondansetron risks cleft lip in 1st trimester)

Question 7

pain prescribing pathway in pregnancy

Answer 7

paracetamol > codeine

Question 8

why are NSAIDs avoided in pregnnacy?

Answer 8

increased risk of premature closure of PDA (especially >30 weeks)