4th Year Pharmacology Flashcards
what is syntocinon?
synthetic oxytocin
role of syntocinon
increases contractions of uterine smooth muscle so used to induce/augment labour and PPH
cautions in syntocinon
bolus can cause hypotension and tachycardia
what is ergometrine?
adrenergic, dopaminergic, 5-HT2 receptor agonist
role of ergometrine
increases contraction of uterine smooth muscle and used in PPH
cautions in ergometrine
asthma
hypertension
what is carboprost?
synthetic prostaglandin F2a
role of carboprost?
increases contraction of uterine smooth muscle and is used in PPH
adverse of carboprost?
bronchoconstriction
hypertension/cardiac
what is misoprostol?
synthetic prostaglandin E1 analogue used in PPH, termination and miscarriage
caution in misoprostol
caution in asthmatics
what is prostin E2/ propess dinoprostone?
prostaglandin E2
what does prostin E2/ propess dinoprostone do?
cervical effacement
adverse of prostin E2/ propess dinoprostone?
uterine hyperstimulation
what is nifedipine?
CCB
use of nifedipine in pregnancy
tocolytic that reduces contraction of uterine smooth muscle
when to avoid nifedipine
aortic stenosis or coarctation
what is magnesium sulphate?
naturally occurring mineral
role of magnesium sulphate
smooth muscle relaxation used in eclampsia and protection of neonatal brain
adverse of magnesium sulphate
hypotonia and resp depression
when to beware of use of magneisum sulphate?
urine <100ml in 4 hours
deep tendon reflexes absent
RR <10
UTI management in pregnancy
- 1st + 2nd tri is nitrofurantoin
- 3rd trimethoprim
2nd line in any tri is cefalexin
antibiotics for sepsis in pregnancy
amox
clind or co-trimox
