Endometrial Cancer Flashcards
peak age of endometrial cancer
50-60
genetic predispositions to endometrial cancer
PCOS
Lynch Syndrome
RF for endometrial cancer
oestrogen exposure
obesity
why is obesity a RF for endometrial cancer?
adipocytes express aromatase that converts ovarian androgens to oestrogen
presentation of endometrial cancer
weight loss
PMB
diagnosis of endometrial cancer
TVUS
MRI and CT
management of endometrial cancer
TAH + BSO
lymphadenopathy
radio + chemo
what is lynch syndrome?
high risk of colorectal and endometrial cancer due to AD DNA mismatch repair geneswith MSI
types of uterine fibroids
pedunculated
intramural
submucous
subserosal
malignant change of fibroid
leiomyosarcoma
presentation of fibroids
asymptomatic menorrhagia bulky uterus urgency, frequency acute abdomen in torsion or degeneration
management of fibroids
GnRH agonists
resection
myomectomy, hysterectomy
embolisation
how are GnRh agonists given?
injections once a month
risks OP >6months
