Pharmacokinetics DLA Flashcards
What are the principles of pharmacokinetics?
What are the mechanisms of drug permeation?
What is absorption?
What are the enteral routes?
What are the parenteral routes?
What are the nonenteral and non parenteral routes?
What are the effects of pH on drug absorption?
What is ion trapping?
How does surface area affect drug absorption?
How does blood flow affect absorption?
How does contact time affect absorption?
What’s the importance of P-glycoproteins?
What is bioavailability and how do we calculate it?
Discuss drug formulation
How does chemical instability affect bioavailability?
Describe how food and drug interactions affect bioavailability
How does first pass hepatic metabolism have an affect on bioavailability ?
How does drug liposolubility affect drug bioavailability ?
What are the two main mechanisms of drug elimination?
- Metabolism of liver
- unchanged drug by kidneys
Describe the metabolism of drugs
Describe phase 1 of reactions of drugs metabolism
Describe pharmaceutical equivalence and bioequivalence
Describe phase II pharmaceutical drug reactions of drug metabolism
What are the sites of drug metabolism?
How do drugs bind to plasma proteins?
How do drugs bind to tissues?
What enzyme is pivotal to phase 1 drug metabolism?
How important are human P450?
What are the molecular mechanisms P450?
What are the clinical consequences of cytochrome P450 induction?
What are the mechanisms and consequences of P450 inhibition?
What’s the impact of P-glycoprotein on drug transport?
How does toxic metabolism affect P450?
What are the genetic factors of drug metabolism?
What are the roles of diet & environment on drug metabolism?
How is drug metabolism affected by age?
How is drug metabolism affected by diseases?
How can drugs be excreted?
Describe renal excretion of drugs
Describe biliary excretion
