NSAIDs Flashcards

1
Q

What are NSAIDs?

A
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2
Q

What are the mechanisms of action of NSAIDs?

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3
Q

What is arachidonate?

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4
Q

What is arachidonic acid?

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5
Q

What synthesizes eicosanoids?

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6
Q

What are the mechanism if action of NSAIDs and the difference between the two enzymes affected?

A
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7
Q

What is the use of COX 2?

A
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8
Q

Where is COX-2 constitutive?

A
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9
Q

Why do some NSAIDs cause gastric damage?

A
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10
Q

What are the NSAIDs?

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11
Q

What are the actions of NSAIDs?

A
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12
Q

What are the main uses of NSAIDs?

A
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13
Q

How do NSAIDs help with colon cancer?

A
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14
Q

How do NSAIDs help with niacin tolerability?

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15
Q

How can NSAIDs be used to treat ductus arteriosus?

A
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16
Q

What are the adverse effects of NSAIDs?

A
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17
Q

What are the GI adverse effects of NSAIDs?

A
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18
Q

What are the relative risks of GI adverse effects of NSAIDs?

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19
Q

What are cardiovascular adverse effects of NSAIDs?

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20
Q

Describe COX-2 selective inhibition & CV risk

A
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21
Q

Contrast CO-1 & COX-2 CV and GI risk

A
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22
Q

What is celecoxib?

A
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23
Q

What are Rofecoxib and Valdecoxib?

A
24
Q

What is Meloxicam?

A
25
Q

What are the renal adverse effects of NSAIDs?

A
26
Q

How NSAIDs decrease blood flow?

A
27
Q

Illustrate the decrease in blood flow by NSAIDs

A
28
Q

What is Analgesic Neuropathy?

A
29
Q

What are the renal effects of COX-2 inhibitors?

A
30
Q

What is NERD? What are its symptoms ?

A
31
Q

What are the causes of NERD?

A
32
Q

What is an adverse effect of celecoxib?

A
33
Q

What is the FDA warning of black box warning for non-aspirin NSAIDs?

A
34
Q

What are the drug interactions of NSAIDs?

A
35
Q

How do ACE-inhibitors interact with NSAIDs?

A
36
Q

What are the drug interactions of diuretics and NSAIDs?

A
37
Q

Describe the triple whammy of NSAIDs drug interactions

A
38
Q

How do corticosteroids interact with NSADs?

A
39
Q

How does warfarin interact with NSAIDs?

A
40
Q

What is Reye’s syndrome ?

A
41
Q

Is pregnancy a contraindication?

A
42
Q

What are Salicylates?

A
43
Q

Why is Aspirin unique among the NSAIDs?

A
44
Q

What are the respiratory actions of aspirin & other salicylates?

A
45
Q

Whaat are the effects of aspirin & other salicylates on platelets?

A
46
Q

What are the main uses of aspirin?

A
47
Q

What are the cardiovascular uses of aspirin?

A
48
Q

What is Kawasaki disease?

A
49
Q

How is dosage of aspirin administered?

A
50
Q

How does aspirin dosage administered?

A
51
Q

Describe aspirin metabolism

A
52
Q

Describe aspirin adverse effects

A
53
Q

Describe salicylate intoxication

A
54
Q

What is Acetaminophen?

A
55
Q

Describe the main uses of Acetaminophen

A
56
Q

What are the adverse effects acetaminophen?

A