Clinical Pharmacokinetics DLA

Question 1

What are the aims of pharmacokinetics?

Answer 1

Question 2

What are the three main parameters of clinical pharmacokinetics?

Answer 2

Question 3

What is volume of distribution?

Answer 3

Question 4

What does amount of Vd indicate?

Answer 4

Question 5

What are the uses of Vd?

Answer 5

Question 6

How do we determine Vd?

Answer 6

Question 7

What is clearance?

Answer 7

Question 8

How do we find rate of elimination?

Answer 8

Question 9

Why do most drugs follow first order kinetics?

Answer 9

Question 10

What are the properties of first order kinetics?

Answer 10

Question 11

What is half life?

Answer 11

Question 12

How do we calculate half life?

Answer 12

Question 13

When do we assume steady state?

Answer 13

Question 14

What are the effects of Vd on half life?

Answer 14

Obesity & pathologic fluid

Question 15

What are the effects of CL on half life?

Answer 15

Ageing
CYP induction & inhibition 
Cardiac failure
Liver failure
Renal failure

Question 16

What’s the effect of obesity on half life?

Answer 16

Increased

Question 17

What are the effects of pathologic fluid on half life?

Answer 17

Increased

Question 18

How can ageing affect half life?

Answer 18

Increased

Question 19

How does CYP induction affect half life?

Answer 19

Decreased

Question 20

How does CYP inhibition affect half life?

Answer 20

Increased

Question 21

How does cardiac failure affect half life?

Answer 21

Increased

Question 22

How does liver failure affect half life?

Answer 22

Increased

Question 23

How does renal failure affect half life?

Answer 23

Increased

Question 24

How does saturation kinetics affect rate of elimination ?

Answer 24

Question 25

How does saturation kinetics affect rate of elimination?

Answer 25

Question 26

What’s the impact of zero order kinetics?

Answer 26

Question 27

Contrast first and zero order kinetics and their therapeutic window interaction

Answer 27

Question 28

How do we design a dosage regimen?

Answer 28

Question 29

What is a therapeutic window ?

Answer 29

Question 30

What is a maintenance dose?

Answer 30

Question 31

What’s the importance of constant steady state in infusion medication?

Answer 31

Question 32

Contrast constant infusion with or without loading dose

Answer 32

Question 33

What does a single IV injection look like?

Answer 33

Question 34

What does multiple IV injections look like?

Answer 34

Question 35

How do we calculate accumulation factor?

Answer 35

Question 36

How do we calculate loading dose with intermittent dosing?

Answer 36

Question 37

What does oral intake of medication look like?

Answer 37

Question 38

Contrast different rates of absorption

Answer 38

Question 39

How can we calculate maintenance dose?

Answer 39

Question 40

Explain the time course drug effect

Answer 40

Question 41

Why can drug with a short half life maintain its effect throughout the day?

Answer 41

Question 42

What can we get by visually representing duration of drug effect?

Answer 42

Question 43

What are the important pharmacokinetics equations?

Answer 43