Clinical Pharmacokinetics DLA Flashcards by Jhaunte Braithwaite

Q

What are the aims of pharmacokinetics?

A

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Q

What are the three main parameters of clinical pharmacokinetics?

A

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Q

What is volume of distribution?

A

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Q

What does amount of Vd indicate?

A

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Q

What are the uses of Vd?

A

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Q

How do we determine Vd?

A

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Q

What is clearance?

A

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Q

How do we find rate of elimination?

A

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Q

Why do most drugs follow first order kinetics?

A

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Q

What are the properties of first order kinetics?

A

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Q

What is half life?

A

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Q

How do we calculate half life?

A

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Q

When do we assume steady state?

A

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Q

What are the effects of Vd on half life?

A

Obesity & pathologic fluid

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Q

What are the effects of CL on half life?

A

Ageing
CYP induction & inhibition 
Cardiac failure
Liver failure
Renal failure

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Q

What’s the effect of obesity on half life?

A

Increased

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Q

What are the effects of pathologic fluid on half life?

A

Increased

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Q

How can ageing affect half life?

A

Increased

Q

How does CYP induction affect half life?

A

Decreased

Q

How does CYP inhibition affect half life?

A

Increased

Q

How does cardiac failure affect half life?

A

Increased

Q

How does liver failure affect half life?

A

Increased

Q

How does renal failure affect half life?

A

Increased

Q

How does saturation kinetics affect rate of elimination ?

A

Q

How does saturation kinetics affect rate of elimination?

A

Q

What’s the impact of zero order kinetics?

A

Q

Contrast first and zero order kinetics and their therapeutic window interaction

A

Q

How do we design a dosage regimen?

A

Q

What is a therapeutic window ?

A

Q

What is a maintenance dose?

A

Q

What’s the importance of constant steady state in infusion medication?

A

Q

Contrast constant infusion with or without loading dose

A

Q

What does a single IV injection look like?

A

Q

What does multiple IV injections look like?

A

Q

How do we calculate accumulation factor?

A

Q

How do we calculate loading dose with intermittent dosing?

A

Q

What does oral intake of medication look like?

A

Q

Contrast different rates of absorption

A

Q

How can we calculate maintenance dose?

A

Q

Explain the time course drug effect

A

Q

Why can drug with a short half life maintain its effect throughout the day?

A

Q

What can we get by visually representing duration of drug effect?

A

Q

What are the important pharmacokinetics equations?

A