Pharmacogenetics Flashcards
What are the potential benefits of pharmacogenomics?
More powerful medicines and lesser side effects
Better vaccines
Decreased cost of hospitalization
Variability in drug response is due to what intrinsic factors?
Genetic difference
Developmental stage
Sex
Protection or susceptibility to urinary and colorectal cancer when exposed to certain xenobiotics may be associated with genes that encode for?
NAT2
True or false, in the presence of thiopurine S methyltransferase deficiency, the dose of 6-mercaptopurine may be decreased to as low as 5% of the standard dose?
True
Which phase II metabolizing enzyme require a very significant dose reduction in the presence of a deficiency?
TMPT
Which of the following is associated with polymorphisms resulting from pharmacodynamic variations: slow acetylator phenotype, aminoglycoside induced deafness, warfarin resistance and warfarin sensitivity?
Warfarin resistance
Pharmacokinetic variations involve?
Transporters
Metabolizing enzymes
What deficiency is associated with hemolysis with primaquine?
G6PD deficiency
What deficiency is associated with prolonged apnea from the use of succinylcholine?
Pseudocholinesterase deficiency
What is associated with trimodal distribution of isoniazid metabolism?
N-acetyl transferase
What is related to cyanosis associated with abnormal hemoglobin following exposure to xenobiotics?
Methemoglobin reductase deficiency
What do call a variation in at least 1% of the population?
Genetic polymorphism
What is the prodrug used in the pharmacogenetic study of CYP2D6?
Debrisoquine
Which is the most common type of polymorphism in the human genome?
Single nucelotide polymorphism (SNP)
Administration of 6-mercaptopurine will have what undesirable effect?
Profound myelosuppression
