Introduction to CNS and Autonomic Pharmacology

Question 1

Which of the following is predominantly sympathetic or adrenergic: heart, arterioles, urinary bladder and ciliary muscle?

Answer 1

Arterioles

Question 2

Which serotonin is ligand gated?

Answer 2

5-HT3

Question 3

Which of the following is the blood brain barrier less impermeable: cerebral ischemia, premature infants, area postrema and median eminence?

Answer 3

All

Question 4

What are the characteristics of voltage-gated sodium channels?

Answer 4

Mediates signal from the cell body to the nerve terminal

Question 5

True or false, G protein directly activates ion channels?

Answer 5

True

Question 6

Which of the following glutamate channels is partly controlled by ligand gated channels: KA, AMPA and NMDA?

Answer 6

NMDA

Question 7

Norepinephrine enhances excitatory inputs by?

Answer 7

Disinhibition of inhibitory local units

Blocking of potassium conductance

Question 8

Which drug is selective for GABA_b receptor?

Answer 8

Baclofen

Question 9

Which autonomic ganglia acting drug is used to clinically treat hypertension?

Answer 9

Trimethaphan

Question 10

Which drug is responsible for blocking the transport of acetylcholine and forms a false neurotransmitter?

Answer 10

Triethylcholine