Adrenergic Agents and Blockers

Question 1

The ultimate effect of sympathetic system is mediated by the release of?

Answer 1

Norepinephrine from nerve terminal

Question 2

What is the mechanism of action of an indirect adrenergic agonist?

Answer 2

Inhibit reuptake of norepinephrine from the synaptic cleft

Question 3

Stimulation of ß₂ receptor leads to?

Answer 3

Glycogenolysis

Question 4

Methyldopa is an α-adrenergic agonist that is?

Answer 4

α₂ selective

Question 5

Activation of α₁ receptor will stimulate?

Answer 5

Phospholipase c

Question 6

What adrenergic system is found predominantly in the heart?

Answer 6

ß₁

Question 7

An α₂ receptor is coupled to what?

Answer 7

G protein

Question 8

An adrenergic agonist which can dilate splanchnic and renal vasculature and can increase contraction and peripheral vascular resistance?

Answer 8

Dopamine

Question 9

ß₂ adrenergic agonist are useful in which condition?

Answer 9

Pre-term labor

Question 10

Bradycardia observed in norepinephrine can be explained by?

Answer 10

Baroreceptor reflex

Question 11

The prolonged mechanism of action of ephedrine is due to?

Answer 11

Substitution of the α-carbon

Question 12

Post-synaptic activation of α₁ receptor will lead to?

Answer 12

Nasal decongestion

Question 13

An adolescent brought to the emergency room presenting with aggressive behavior, anxiety, paranoid state, hypertension and tachycardia was diagnosed to have metamphetamine abuse. What is the action of amphetamine?

Answer 13

It displaces norepinephrine from vesicles

Question 14

What is the side effect of post-synaptic α receptor blockade?

Answer 14

Orthostatic hypotension

Question 15

ß blockers are avoided in diabetics because?

Answer 15

It masks symptoms of hypolgycemia

Question 16

ß blockers are contraindicated in?

Answer 16

Asthma

History of cocaine use or cocaine induced tachycardia

Question 17

What drug is a ß₁ selective blocker with the shortest half life?

Answer 17

Esmolol

Question 18

What drug is a non-selective ß blocker?

Answer 18

Propanolol

Question 19

What drug is a non-selective ß and α antagonist?

Answer 19

Carvedilol

Question 20

What drug is a non-selective ß blocker with partial agonist activity?

Answer 20

Pindolol

Question 21

Sympathetic activations leads to: alertness, peristalsis and bladder contraction?

Answer 21

Alertness

Question 22

Activation of this receptor found in the pre-synaptic membrane will inhibit neurotransmitter release?

Answer 22

α₂