Autacoids Flashcards
True or false, H4 receptors are found in bone marrow and white blood cells?
True
Which is not a function of 5-HT: regulation of GI motility and presitalsis, bronchodilation, chemical transmitter for tryptaminergic neurons of the brain and precursor of melatonin?
Bronchodilation
Which is not an H1 antagonist: chlorphenamine, fexofenadine, cimetidine and loratidine?
Cimetidine
Ranitidine
True or false, cisapride is a 5-HT4 agonist for anxiety and depression?
False
Cisapride is for GI motility and presitalsis. Buspirone is for anxiety and depression.
True or false, tissue damage cannot activate kallikrein-kininogen-kinin system?
False
What vasoactive compound is the most potent vasoconstrictor?
Angiotensin II
What drug is considered as a renin inhibitor?
Aliskerin
What drug is a non-selective 5-HT receptor antagonist?
Ergotamin
Gastrointestinal bleeding from aspirin is considered a?
Side effect
Prostaglandin synthesis is blocked through what pathway?
Cyclooxygenase pathway
The potency of ACE inhibitors like captopril can be explained by a dual action of?
Inhibition of synthesis of a powerful vasoconstrictor
Inhibition of destruction of a powerful vasodilator
Angiotensin effects are reversed by?
Renin inhibitors
Angiotensin converting enzyme inhibitors
kininase II inhibitors
angiotensin receptor antagonist
What drug is a selective serotonin widely used anxiolitic?
Buspirone
5-HT in brain serotogenic neurons are involved in?
Mood, depression, anxiety
Sleep, apetite, vomitting
Pain, temperature regulation, migraine
Serotonin is found in?
Enterochromaffin cells
Platelets which are able to concentrate the amine by means of active SERT
Nerve endings particularly brain serotogenic neurons as transmitter
What is an example of a traditional antihistamines with sedative effects?
Diphenhydramine
Histamine has the following?
Powerful effects on smooth and cardiac muscles
Endothelial cells and nerves
More effect on guinea pigs than humans
Gastric acid secretion
What drug is an example of a lipoxygenase inhibitor?
Zileuton
What drugs are an example of leukotriene-receptor antagonist?
Montelukast
Zafirlukast
What drug is an example of a selective COX-2 inhibitor?
Celecoxib
What drug is an analog of PGE2 and used to reduce NSAID induced ulcers?
Misoprostol
What anti-inflammatory drug binds uniquely to its receptor irreversibly?
Aspirin
What enzymes are inhibited by NSAIDs like aspirin and ibuprofen?
COX-1
COX-2
What are the clinical significance of prostanoids?
Platelet function
Inflammatory reaction
Reproduction
What enzyme classes are responsible for converting tryptophan to serotonin?
Hydroxylase
Decarboxylase
What body functions involve 5-HT?
Fertility
Feeding
Mentation
What are the therapeutic uses of H1 blockers?
Aid for sleeping
Countering motion sickness
Relieve itching and rashes in allergies
Which of the following drugs is least sedating: loratadine, chlorpenamine, diphenhydramine and clemastine?
Loratadine
What autacoids are involved in inflammation?
Histamine
Bradykinin
Serotonin
Prostanoids
