Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology LU IV > Autacoids > Flashcards

Autacoids Flashcards

1
Q

True or false, H4 receptors are found in bone marrow and white blood cells?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which is not a function of 5-HT: regulation of GI motility and presitalsis, bronchodilation, chemical transmitter for tryptaminergic neurons of the brain and precursor of melatonin?

A

Bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which is not an H1 antagonist: chlorphenamine, fexofenadine, cimetidine and loratidine?

A

Cimetidine

Ranitidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

True or false, cisapride is a 5-HT4 agonist for anxiety and depression?

A

False

Cisapride is for GI motility and presitalsis. Buspirone is for anxiety and depression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

True or false, tissue damage cannot activate kallikrein-kininogen-kinin system?

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What vasoactive compound is the most potent vasoconstrictor?

A

Angiotensin II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What drug is considered as a renin inhibitor?

A

Aliskerin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What drug is a non-selective 5-HT receptor antagonist?

A

Ergotamin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Gastrointestinal bleeding from aspirin is considered a?

A

Side effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Prostaglandin synthesis is blocked through what pathway?

A

Cyclooxygenase pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The potency of ACE inhibitors like captopril can be explained by a dual action of?

A

Inhibition of synthesis of a powerful vasoconstrictor

Inhibition of destruction of a powerful vasodilator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Angiotensin effects are reversed by?

A

Renin inhibitors

Angiotensin converting enzyme inhibitors

kininase II inhibitors

angiotensin receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What drug is a selective serotonin widely used anxiolitic?

A

Buspirone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

5-HT in brain serotogenic neurons are involved in?

A

Mood, depression, anxiety

Sleep, apetite, vomitting

Pain, temperature regulation, migraine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Serotonin is found in?

A

Enterochromaffin cells

Platelets which are able to concentrate the amine by means of active SERT

Nerve endings particularly brain serotogenic neurons as transmitter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is an example of a traditional antihistamines with sedative effects?

A

Diphenhydramine

17
Q

Histamine has the following?

A

Powerful effects on smooth and cardiac muscles

Endothelial cells and nerves

More effect on guinea pigs than humans

Gastric acid secretion

18
Q

What drug is an example of a lipoxygenase inhibitor?

A

Zileuton

19
Q

What drugs are an example of leukotriene-receptor antagonist?

A

Montelukast

Zafirlukast

20
Q

What drug is an example of a selective COX-2 inhibitor?

A

Celecoxib

21
Q

What drug is an analog of PGE2 and used to reduce NSAID induced ulcers?

A

Misoprostol

22
Q

What anti-inflammatory drug binds uniquely to its receptor irreversibly?

A

Aspirin

23
Q

What enzymes are inhibited by NSAIDs like aspirin and ibuprofen?

A

COX-1

COX-2

24
Q

What are the clinical significance of prostanoids?

A

Platelet function

Inflammatory reaction

Reproduction

25
Q

What enzyme classes are responsible for converting tryptophan to serotonin?

A

Hydroxylase

Decarboxylase

26
Q

What body functions involve 5-HT?

A

Fertility

Feeding

Mentation

27
Q

What are the therapeutic uses of H1 blockers?

A

Aid for sleeping

Countering motion sickness

Relieve itching and rashes in allergies

28
Q

Which of the following drugs is least sedating: loratadine, chlorpenamine, diphenhydramine and clemastine?

A

Loratadine

29
Q

What autacoids are involved in inflammation?

A

Histamine

Bradykinin

Serotonin

Prostanoids

Pharmacology LU IV (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions