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Pharmacology LU IV > Antifungals > Flashcards

Antifungals Flashcards

0
Q

What antifugal has the broadest spectrum?

A

Amphotericin B

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1
Q

What is the MOA of amphotericin B?

A

Binds to ergosterol and forms membrane pores allowing leakage of electrolyte

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2
Q

What is the MOA of nystatin?

A

Binds to ergosterol and forms membrane pores allowing leakage of electrolyte

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3
Q

What is the formulation of nystatin?

A

Topical form

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4
Q

What is the MOA of azole?

A

Inhibits ergosterol synthesis by inhibiting the P450 enzyme that converts lanosterol to ergosterol

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5
Q

What is the MOA of flucytosine?

A

Inhibits DNA and RNA biosynthesis by conversion to 5-fluorouracil by cytosine deaminase

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6
Q

What are the fungicidal drugs?

A

Polyene

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7
Q

True or false, imidazoles have poor CNS penetration?

A

True

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8
Q

What drugs are clinically indicated for cryptococcal meningitis?

A

Amphotericin B

Flucytosine

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9
Q

What azole has the most specific inhibition of fungal cytochrome P450 than human microsomal enzymes?

A

Fluconazole

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10
Q

What antifungal is used for serious systemic mycoses?

A

Amphotericin B

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11
Q

What antifungal is used for local and less serious systemic mycoses?

A

Azole

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12
Q

What is the drug of choice for onychomycosis?

A

Terbinafine

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13
Q

What antifungal is contraindicated to drugs metabolized by the liver?

A

Azole

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14
Q

What is the drug of choice for mucormycosis?

A

Amphotericin B

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15
Q

What is the effective drug for tinea cruris and tinea corporis?

A

Terbinafine

16
Q

What is the MOA of terbinafine?

A

Inhibits the fungal enzyme squalene epoxidase

17
Q

What is the MOA of griseofulvin?

A

Interferes with microtubule function and disrupts mitosis

18
Q

What are the AE of griseofulvin?

A

Teratogenic

Carcinogenic

Confusion

Headache

Increased P450 and warfarin metabolism

Pharmacology LU IV (12 decks)

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