Antivirals

Question 0

What is the MOA of acyclovir?

Answer 0

Inhibits viral DNA polymerase by chain termination

Question 1

What is the MOA of zanamivir and oselatamivir?

Answer 1

Inhibit influenza neuraminidase decreasing release of viral progeny

Question 2

What antiviral is used for herpes zoster?

Answer 2

Famciclovir

Question 3

What is the MOA of ribavirin?

Answer 3

Inhibits synthesis of guanine nuleotides by completely inhibiting IMP dehydrogenase

Question 4

What is a prodrug of acyclovir with better oral bioavailability?

Answer 4

Valacyclovir

Question 5

What is the MOA of ganciclovir?

Answer 5

Inhibits viral DNA polymerase preferentially

Question 6

What prodrug of ganciclovir has better oral bioavailability?

Answer 6

Valganciclovir

Question 7

What antiviral is used for CMV?

Answer 7

Ganciclovir

Question 8

What antiviral is used for HSV and VZV?

Answer 8

Acyclovir

Question 9

What antiviral is used for influenza A and B?

Answer 9

Zanamivir

Oseltamivir

Question 10

What are the AE of nucleoside reverse transcriptase inhibitors?

Answer 10

Lactic acidosis

Hepatic steatosis

Dyslipidemia

Question 11

What is the recommended first line antiretroviral therapy in the Philippines?

Answer 11

Zidovudine (AZT) + Lamivudine (3TC) + Nevirapine (NVP)

Question 12

Ritonavir is a potent inhibitor of what enzyme?

Answer 12

CYP3A4

Question 13

What is the most recommended protease inhibitor?

Answer 13

Atazanivir