[PHARMA] ANTIEPILEPTICS

Question 1

can cause stevens johnson syndrome

Answer 1

lamotrigine

Question 2

topriamate SF

Answer 2

renal stones
myopia (–>glaucoma)
weight loss
hypohydrosis

Question 3

levetiracetam SF

Answer 3

mood & behavioral changes

Question 4

Lamotrigine drug interactions

Answer 4

valproate (-) its metabolism
OC & carbamazepine increase its metabolism

Question 5

lamotrigine SF

Answer 5

stevens johnson syndrome
hypersensitivity

Question 6

drugs which block Na channels

Answer 6

valproate
carbamazepine
phenytoin
topiramate
lamotrigine

Question 7

drugs which block T-Ca++ channels

Answer 7

Ethosuximide
valproate

Question 8

drugs which block presynaptic voltage gated Ca++ channels

Answer 8

lamotrigine

Question 9

drugs which bind to VS2A

Answer 9

levetriacetam

Question 10

NMDA-R antagonist

Answer 10

valproate

Question 11

drugs which facilitate GABA

Answer 11

BZDs
phenobarbitals
topiramate

Question 12

drugs which increase GABA turnover & levels

Answer 12

valproate

Question 13

valproate is preferred over ethosuximide in

Answer 13

tonic clonic + myoclonic coexisting

Question 14

phenytoin is used in

Answer 14

partial
tonic clonie

Question 15

prodrug of phenytoin

Answer 15

fosphenytoin

Question 16

fosphenytoin is used in

Answer 16

status epilepticus

Question 17

advantages of fosphenytoin

Answer 17

IM or IV
better bioavailability
less phlebitis
less cardiac SF

Question 18

analog of carbamazepine

Answer 18

oxycarbazepine

Question 19

characteristics of oxycarbazepine

Answer 19

less potent
less side effects

Question 20

phenobarbital & BZDs are limited to use in

Answer 20

status epilepticus
acute fits

Question 21

phenytoin
carbamazepine
oxycarabazepine are contraindicated in

Answer 21

abscence
myoclinic

Question 22

hypersensitivity in phenytoin

Answer 22

skin rash

Question 23

hypersensitivity in carbamazepine

Answer 23

skin rask

Question 24

hypersensitivity in valproate

Answer 24

skin rash

Question 25

GIT disturbance in phenytoin,carbamazepine & valproate

Answer 25

nausea vomiting epigastric pain

Question 26

neurological disturbances in phenytoin

Answer 26

nystagmus diplopia drowsiness ataxia decreased learning in children

Question 27

neurological disturbances in carbamazepine

Answer 27

diplopia drowsiness ataxia

Question 28

neurological disturbances in valproate

Answer 28

tremors ataxia less sedative

Question 29

effects on hepatic enzymes by phenytoin

Answer 29

enzyme inducer increase vit D metabolism=osteomalacia

Question 30

effects on hepatic enzymes by carbamazepine

Answer 30

enzyme inducer

Question 31

effects on hepatic enzymes by valproate

Answer 31

enzyme inhibitor

Question 32

hematological effects of phenytoin

Answer 32

megaloblastic anemia lymphadenopathy

Question 33

hematological effects of carba

Answer 33

leukopenia agranulocytosis

Question 34

hematological effects of valproate

Answer 34

thrombocytopenia

Question 35

teratogenicity of phenytoin

Answer 35

cleft palate lip-heart anomalies

Question 36

teratogenicity of carba

Answer 36

less

Question 37

teratogenicity of valproate

Answer 37

spina bifida neural crest tube defect

Question 38

cosmetic changes in phenytoin

Answer 38

gingival hyperplasia histrutism acne coarse facial features

Question 39

affects of carba on ADH & water

Answer 39

potentiates ADH water intoxication & dilutional hyponatremia

Question 40

other SF of valproate

Answer 40

hepatotoxicityy hair loss polycystic ovaries increased appetite increase body weight

Question 41

other SF of valproate

Answer 41

hepatotoxicity hair loss polycystic ovaries increased appetite increase body weight

Question 42

ethosuxamide SF

Answer 42

git upset skin rash dizziness drowsiness headache

Question 43

safest antiepileptic

Answer 43

ethosuxamide

Question 44

drug withdrawal period

Answer 44

6 months

Question 45

what must be given to a child bearing woman to avoid statis epilepticus/relapse

Answer 45

folic acid supplements

Question 46

effect of pregnancy on the efficacy of antiepileptics

Answer 46

decreases their metabolism

Question 47

what limits the use of phenobarbital

Answer 47

sedation & tolerance

Question 48

drugs preferred in elderly

Answer 48

lamotrigine levetriacetam carbamazepine

Question 49

drugs used is status epilepticus

Answer 49

BZDs phenobarbital fosphenytoin/phenytoin IV anesthetics IV antiepileptics

Question 50

when are IV anesthetics given to control seizures

Answer 50

resistant cases

Question 51

IV antiepileptics

Answer 51

valproate levetriacetam

Question 52

long acting drugs used to maintain control established by BZDs in status epilepticus

Answer 52

fosphenytoin/phenytoin

Question 53

mood stabilizing antiepileptics

Answer 53

lamotrigine carba valproate

Question 54

neuropathic pain TTT by

Answer 54

carba

Question 55

antiarrhythmatic

Answer 55

phenytoin

Question 56

migraine

Answer 56

valproate topiramate