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CNS > [PHARMA] ANTIEPILEPTICS > Flashcards

[PHARMA] ANTIEPILEPTICS Flashcards

1
Q

can cause stevens johnson syndrome

A

lamotrigine

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2
Q

topriamate SF

A

renal stones
myopia (–>glaucoma)
weight loss
hypohydrosis

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3
Q

levetiracetam SF

A

mood & behavioral changes

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4
Q

Lamotrigine drug interactions

A

valproate (-) its metabolism
OC & carbamazepine increase its metabolism

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5
Q

lamotrigine SF

A

stevens johnson syndrome
hypersensitivity

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6
Q

drugs which block Na channels

A

valproate
carbamazepine
phenytoin
topiramate
lamotrigine

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7
Q

drugs which block T-Ca++ channels

A

Ethosuximide
valproate

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8
Q

drugs which block presynaptic voltage gated Ca++ channels

A

lamotrigine

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9
Q

drugs which bind to VS2A

A

levetriacetam

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10
Q

NMDA-R antagonist

A

valproate

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11
Q

drugs which facilitate GABA

A

BZDs
phenobarbitals
topiramate

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12
Q

drugs which increase GABA turnover & levels

A

valproate

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13
Q

valproate is preferred over ethosuximide in

A

tonic clonic + myoclonic coexisting

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14
Q

phenytoin is used in

A

partial
tonic clonie

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15
Q

prodrug of phenytoin

A

fosphenytoin

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16
Q

fosphenytoin is used in

A

status epilepticus

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17
Q

advantages of fosphenytoin

A

IM or IV
better bioavailability
less phlebitis
less cardiac SF

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18
Q

analog of carbamazepine

A

oxycarbazepine

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19
Q

characteristics of oxycarbazepine

A

less potent
less side effects

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20
Q

phenobarbital & BZDs are limited to use in

A

status epilepticus
acute fits

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21
Q

phenytoin
carbamazepine
oxycarabazepine are contraindicated in

A

abscence
myoclinic

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22
Q

hypersensitivity in phenytoin

A

skin rash

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23
Q

hypersensitivity in carbamazepine

A

skin rask

24
Q

hypersensitivity in valproate

A

skin rash

25
Q

GIT disturbance in phenytoin,carbamazepine & valproate

A

nausea
vomiting
epigastric pain

26
Q

neurological disturbances in phenytoin

A

nystagmus
diplopia
drowsiness
ataxia
decreased learning in children

27
Q

neurological disturbances in carbamazepine

A

diplopia
drowsiness
ataxia

28
Q

neurological disturbances in valproate

A

tremors
ataxia
less sedative

29
Q

effects on hepatic enzymes by phenytoin

A

enzyme inducer
increase vit D metabolism=osteomalacia

30
Q

effects on hepatic enzymes by carbamazepine

A

enzyme inducer

31
Q

effects on hepatic enzymes by valproate

A

enzyme inhibitor

32
Q

hematological effects of phenytoin

A

megaloblastic anemia
lymphadenopathy

33
Q

hematological effects of carba

A

leukopenia
agranulocytosis

34
Q

hematological effects of valproate

A

thrombocytopenia

35
Q

teratogenicity of phenytoin

A

cleft palate
lip-heart anomalies

36
Q

teratogenicity of carba

A

less

37
Q

teratogenicity of valproate

A

spina bifida
neural crest tube defect

38
Q

cosmetic changes in phenytoin

A

gingival hyperplasia
histrutism
acne
coarse facial features

39
Q

affects of carba on ADH & water

A

potentiates ADH
water intoxication & dilutional hyponatremia

40
Q

other SF of valproate

A

hepatotoxicityy
hair loss
polycystic ovaries
increased appetite
increase body weight

41
Q

other SF of valproate

A

hepatotoxicity
hair loss
polycystic ovaries
increased appetite
increase body weight

42
Q

ethosuxamide SF

A

git upset
skin rash
dizziness
drowsiness
headache

43
Q

safest antiepileptic

A

ethosuxamide

44
Q

drug withdrawal period

A

6 months

45
Q

what must be given to a child bearing woman to avoid statis epilepticus/relapse

A

folic acid supplements

46
Q

effect of pregnancy on the efficacy of antiepileptics

A

decreases their metabolism

47
Q

what limits the use of phenobarbital

A

sedation & tolerance

48
Q

drugs preferred in elderly

A

lamotrigine
levetriacetam
carbamazepine

49
Q

drugs used is status epilepticus

A

BZDs
phenobarbital
fosphenytoin/phenytoin
IV anesthetics
IV antiepileptics

50
Q

when are IV anesthetics given to control seizures

A

resistant cases

51
Q

IV antiepileptics

A

valproate
levetriacetam

52
Q

long acting drugs
used to maintain control established by BZDs in status epilepticus

A

fosphenytoin/phenytoin

53
Q

mood stabilizing antiepileptics

A

lamotrigine
carba
valproate

54
Q

neuropathic pain TTT by

A

carba

55
Q

antiarrhythmatic

A

phenytoin

56
Q

migraine

A

valproate
topiramate

CNS (29 decks)

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