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[MICRO] BACTERIAL MENINGITIS Flashcards

1
Q

Gram +ve agents

A

Clostridium
GBS
Pneumococci
Listeria

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2
Q

Gram -ve agents

A

Neisseria
H.influenza

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3
Q

gram +ve
spore forming
motile bacilli
non capsulated

A

Clostridium

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4
Q

Habitat of clostridium

A

GIT (human+animals)
Soil

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5
Q

isolation of clostridium is done by

A

Robertson cooked meat media–>blood agar @ 37 degrees, 12 days, anaerobic=
BETA HEMOLYSIS

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6
Q

MOI of tetanus

A

contaminated wound
gun shot
animal bite
contaminated umbilicus
contaminated instruments

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7
Q

source of Cl. tetani

A

soil

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8
Q

virulence of Cl. tetani

A

Tetanospasmin
Tetanolysin

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9
Q

pathogenesis of Tetanus

A

spores germinate @ site of infection
bind to AHCs
(-) GABA+ Glycin
= MUSCLE SPASM

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10
Q

blood invasion in tetanus

A

N/A

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11
Q

incubation period of tetanus

A

1 week

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12
Q

Clinical picture of tetanus

A

muscle spasm
lock jaw, trismus, risus sardonicus
paralysis of respiratory muscles
convulsions

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13
Q

tetanus can be fatal due to

A

paralysis of respiratory muscles

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14
Q

specimen of Cl. tetani

A

wound exudate

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15
Q

toxin detection in tetanus by

A

culturing isolated colony on blood agar containing antitoxin
after incubation: no hemolysis=
✓TOXIN

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16
Q

active immunization in tetanus

A

toxoid DTaP= children + every 10 years
Tdap= adolescents+ adults= booster

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17
Q

passive immunization in tetanus

A

antitoxin= 4w protection

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18
Q

TTT of tetanus

A

passive-active immunization (toxoid+antitoxin)
ventilator
dark room
wound cleaning
BZDs

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19
Q

antigenic types of tetanospasmin

A

one type

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20
Q

gram +ve bacilli
H2S +ve
liquefy gelatin

A

Cl. botulinum

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21
Q

antigenic types of botulinum neurotoxin

A

8 antigenically different types

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22
Q

antigenic types of neurotoxin that causes human botulism

A

A,B, E

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23
Q

source of botulism

24
Q

botulism neurotoxin cc

A

8 antigenically different types
A,B,E= human botulism
(-) Ach
Destroyed by heating 100° for 20min
biological warfare level A

25
biological warfare level A
botulism neurotoxin
26
pathogenesis of botulism
1-anaerobic conditions 2-spores vegetation 3-neurotoxin in food 4-ingestion 5- (-) Ach 6- Flaccid paralysis
27
prevention of botulism
proper canning proper cooking discarding swollen cans
28
TTT of botulism
trivalent antitoxin ventilation
29
highest risk foods in case of botulism
alkaline vegetables green beans salted fish mushrooms
30
infantile botulism caused by
ingestion of honey
31
incubation period of Cl.botulinum
3 days
32
Classical botulinum & wound botulinum clinical picture
cranial nerve paralysis diplopia dysphagia
33
git manifestations of botulinum
N/A
34
specimen in botulinum
food, gastric lavage
35
toxin detection in botulinum
PCR Animal testing ELISA
36
neonatal meningitis caused by
GBS E.coli Listeria
37
meningitis in infants caused by
Pneumococci Neisseria H.influenza
38
MOI of meningitis
blood direct extension= OM/sinusitis Trauma to skull
39
MC MOI in meningitis
hematogenous
40
pathogenesis of meningitis
nasopharyngeal colonization blood invasion settle in meninges inflammation edema ↑ ICP
41
Clinical picture of meningitis
FAHM stiff neck floppy baby photophobia high pitched cry
42
GBS causes
neonatal meningitis pneumonia
43
virulence factor of GBS
polysaccharide capsule
44
site of GBS
vagina
45
intermittent commensal of vagina
GBS
46
MOI of GBS
during delivery
47
Risk factors of GBS
prolonged labor rupture of membranes during delivery fever during delivery history of GBS/GBS bacteruria at any trimester
48
specimen of GBS
vaginal & rectal swab @ 35-37 weeks
49
Gram +Ve hippurate hydrolysis CAMP
GBS
50
TTT & prevention of GBS
IV Ampicillin/Penicillin at time of delivery
51
virulence of pneumococci (4)
capsule IgA protease Pneumolysin Autolysin
52
antigenic serotypes of pneumococci capsule
90
53
Gram +ve diplococci surrounded by unstained area alpha hemolysis on choco agar
pnemococci
54
Draughtman's colonies
pnemococci
55
Quelleng reaction
pneumococci
56
isolation of pneumococci
blood/chocolate agar

CNS (29 decks)

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