Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

*KS NPLEX ll > Pharm ll > Flashcards

Pharm ll Flashcards

1
Q

Carbidopa MOA

A

inhibits Dopa Decarboxylase

  • levodopa is the substrate for more dopamine
  • Cat C
  • indic parkinson’s
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 Dopamine agonist for Parkinson’s

A

Pramipexole, Bromocriptine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bromocriptine indic, ADR

A

PD, pituitary tumors, acromegaly

SE: pulmonary fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Anticholinergic indic for PD

if this drug doesn’t work, use what?

A

Benztropine

if not work, diphenhydramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Amantadine MOA

A

antagonizes excitatory NMDA receptors
indic: levodopa induced dyskinesias; influenza-A (rarely)
ADR: exacerbate mental illness, insomnia, hallucinations, NMS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Scopolamine indic

A

N/V assoc w motion sickness, muscle spasms, Parkinson’s like conditions (muscles)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

2 drugs for weight loss
MOA
preg Cat

A

dextroamphetamine
phentermine
MOA: release of Dopa, NE
Phentermine is Cat X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Strattera name

A

Atomoxatine
indic ADHD
suicidal ideation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Modafinil SE

A

SJS, rash, hypertension, etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Drugs indic fo MS

A

glatiramer acetate, fingolimod, interferon beta 1, baclofen, tizanidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Glatiramer acetate
MOA
INDIC
WARNINGS

A 
L-GLUTAMIC ACID POLYMER
MOA is unknown
Immune Modulator (down regulates myelin antigens)
INDIC: MS
WARNING: hypersensitivity 
CAT B
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fingolimod
MOA
INDIC
CI

A

sphingosine 1-phosphate R modulator
MOA: blocks lymphocytes from emerging from lymph nodes
INDIC: MS
CI: concurrent use of class 1a or lll antiarrhythmic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

3 drugs for muscle spasticity

A

botulinum: ACh release inhibitor
baclofen: MOA unknown, not indicated for stroke, must TAPER OFF (hallucinations/seizures)
tizanidine: alpha 2 adrenergic agonist (centrally) - cause sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

2 anti-seizure meds
MOA: NA channel inhibitors
CAT

A

carbamazepine, phenytoin

  • sodium channel inhibitors
  • CAT D
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Phenytoin SE

A

gingival hyperplasia, suicidal behavior

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

GABA analogs indic anti-seizures

A

Gabapentin, Pregabalin
ADR: suicidal behavior, LR toxicity
CAT C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Valproate INDIC

A

anti-convulsant, epilepsy, mania, migraine

SE: suicide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Lamotrigine INDIC

A

epilepsy, bipolar
SE: skin rashes, suicide
CAT C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Atypical Antipsychotics

A 
Risperidone
Quetiapine
Aripiprazole
MOA unknown
SCHIZO
SE: dyslipidemia, dysglycemia, compulsive urges, suicide 
increased mortality in elderly 
CLOZAPINE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Clozapine SE

A

increased mortality in elderly, severe neutropenia, ortho hypo, bradyca, syncope, seizure, myocarditis, cardiomyopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

MAO-I have man drug interactions because

A

CYP450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Thalidomide

A

immunomodulatory
indic: leprosy, Multiple myeloma
CT: X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Tofacitinib

A

JAK inhibitor
DMARD
BB: future CA, risk of fatal infxn
INDIC: RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

DMARDs

A

methotrexate (folate analogue)
sulfasalazine (reduces folate/prodrug of antibiotic)
hydroxychloroquine (SLE, RA, anti-malarial)
penacillamine (Wilson’s Dz, RA, slows joint deformation)
tofacitinib (JAK inhib)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Etancercept
cytokine inhibitor | RA, JA, Psor Arth, plaq psor, AS
26
Adalimumab | Infliximab
cytokine inhibitors TNF-alpha blocker (-mabs) inc risk of serious infn
27
2 drugs for transplants
Cyclosporine | Tacrolimus
28
2 alkylating agents for chemo
cisplatin | cyclophosphamide
29
1 anthracycline for chemo
doxorubicin
30
Anti-Her-2 chemo
trastuzumab
31
Anti-metabolite/anti-folate for chemo
methotrexate
32
Anti-microtubule for chemo
vinblastine
33
Aromatase inhibitor for chemo
anastrozole
34
non-steroidal androgen receptor blocker for chemo
bicalutamide
35
LH-RH agonist/GnRH analogue for chemo
leuprolide
36
Mitotic inhibitor for chemo
paclitaxel
37
Pyrimidine analogue for chemo
5-fluorouracil
38
SERMs for chemo
raloxifene | tamoxifen
39
Polio doses
4
40
Penuomococcal doses
4
41
Meningococcal doses
1 at 11-12 yo | booster at 16 yo
42
MMR | mumpes, measles, rubella
2 | 12-15 mo, 4-6 yrs
43
HPV quad doses
3 11-12 yo, then 1-2 mo later, then 6 mo later can't use HPV2 for males
44
HEP B doses
3 | birth, 1-3 mo, 6-15 mo
45
HEP A doses
2 | 12-23 mo, then 6-18 mo later
46
HIB doses
3 2 mo, 4 mo, 6 mo booster at 12-15 mo
47
DPT doses
4 2 mo, 4, 6, 15 mo | 2 boosters: adolesc, pregN
48
Cholera doses
2 doses 1-6 wks apart no later than 2 wks before travel | 2 yo + adult
49
Adefovir dipivoxil
anti hepatitis B | nucleoside analogue
50
anti hep B and C drug
interferon alpha 2 modulates immune system SE: altered mental state, flulike, ai dz, psychotic
51
Oseltamivir MOA
neuraminidase inhibitor SE: suicide Tamiflu
52
Amantadine INDIC MOA SE
PD, and influenza A MOA: inhibits viral uncoating SE: neuroleptic malig syndrome, mental disorder
53
Zidovudine (AZT) indic
HIV nucleoside analogue, reverse transcriptase inhibitor targets all cells used in drug cocktail
54
Bactrim | bacteriostatic
sulfamethoxazole - travel diarrhea, UTI, OM PABA analogue/ antimetabolite Trimethoprim - UTI, (SE is SJS) folate analogue/antimetabolite
55
nitrofurantoin
urinary tract metabolite CI pregn
56
Fluoroquinolones are... drugs? SE
DNA synthesis inhibitors cipro, levofloxacin INdic: bacteriocidal, tx common infections, gram neg SE: periph neuropathy, cartilage damage, prolonged QT
57
Rifaximin
inhibits bacterial RNA | INDIC: IBD-D, hepatic enceoph
58
Rifampin
inhibits RNA INDIC TB used with isoniazid, pyrazinamide
59
Clindamycin
lincosamide blocks peptide bonds anaerobic infxn, broad spectrum SE: C.diff, pseudomembranous colitis
60
Macrolides drugs 3
Azithromycin Erythromycin Calrithromycin Indic: pulm infxn, mycoplasma pneumonia, chlamydia SE: prolonged QT, acute cholestatic hepatitis

*KS NPLEX ll (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions