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*KS NPLEX ll > Pharm ll > Flashcards

Pharm ll Flashcards

1
Q

Carbidopa MOA

A

inhibits Dopa Decarboxylase

  • levodopa is the substrate for more dopamine
  • Cat C
  • indic parkinson’s
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2
Q

2 Dopamine agonist for Parkinson’s

A

Pramipexole, Bromocriptine

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3
Q

Bromocriptine indic, ADR

A

PD, pituitary tumors, acromegaly

SE: pulmonary fibrosis

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4
Q

Anticholinergic indic for PD

if this drug doesn’t work, use what?

A

Benztropine

if not work, diphenhydramine

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5
Q

Amantadine MOA

A

antagonizes excitatory NMDA receptors
indic: levodopa induced dyskinesias; influenza-A (rarely)
ADR: exacerbate mental illness, insomnia, hallucinations, NMS

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6
Q

Scopolamine indic

A

N/V assoc w motion sickness, muscle spasms, Parkinson’s like conditions (muscles)

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7
Q

2 drugs for weight loss
MOA
preg Cat

A

dextroamphetamine
phentermine
MOA: release of Dopa, NE
Phentermine is Cat X

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8
Q

Strattera name

A

Atomoxatine
indic ADHD
suicidal ideation

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9
Q

Modafinil SE

A

SJS, rash, hypertension, etc

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10
Q

Drugs indic fo MS

A

glatiramer acetate, fingolimod, interferon beta 1, baclofen, tizanidine

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11
Q

Glatiramer acetate
MOA
INDIC
WARNINGS

A 
L-GLUTAMIC ACID POLYMER
MOA is unknown
Immune Modulator (down regulates myelin antigens)
INDIC: MS
WARNING: hypersensitivity 
CAT B
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12
Q

Fingolimod
MOA
INDIC
CI

A

sphingosine 1-phosphate R modulator
MOA: blocks lymphocytes from emerging from lymph nodes
INDIC: MS
CI: concurrent use of class 1a or lll antiarrhythmic

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13
Q

3 drugs for muscle spasticity

A

botulinum: ACh release inhibitor
baclofen: MOA unknown, not indicated for stroke, must TAPER OFF (hallucinations/seizures)
tizanidine: alpha 2 adrenergic agonist (centrally) - cause sedation

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14
Q

2 anti-seizure meds
MOA: NA channel inhibitors
CAT

A

carbamazepine, phenytoin

  • sodium channel inhibitors
  • CAT D
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15
Q

Phenytoin SE

A

gingival hyperplasia, suicidal behavior

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16
Q

GABA analogs indic anti-seizures

A

Gabapentin, Pregabalin
ADR: suicidal behavior, LR toxicity
CAT C

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17
Q

Valproate INDIC

A

anti-convulsant, epilepsy, mania, migraine

SE: suicide

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18
Q

Lamotrigine INDIC

A

epilepsy, bipolar
SE: skin rashes, suicide
CAT C

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19
Q

Atypical Antipsychotics

A 
Risperidone
Quetiapine
Aripiprazole
MOA unknown
SCHIZO
SE: dyslipidemia, dysglycemia, compulsive urges, suicide 
increased mortality in elderly 
CLOZAPINE
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20
Q

Clozapine SE

A

increased mortality in elderly, severe neutropenia, ortho hypo, bradyca, syncope, seizure, myocarditis, cardiomyopathy

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21
Q

MAO-I have man drug interactions because

A

CYP450

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22
Q

Thalidomide

A

immunomodulatory
indic: leprosy, Multiple myeloma
CT: X

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23
Q

Tofacitinib

A

JAK inhibitor
DMARD
BB: future CA, risk of fatal infxn
INDIC: RA

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24
Q

DMARDs

A

methotrexate (folate analogue)
sulfasalazine (reduces folate/prodrug of antibiotic)
hydroxychloroquine (SLE, RA, anti-malarial)
penacillamine (Wilson’s Dz, RA, slows joint deformation)
tofacitinib (JAK inhib)

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25
Q

Etancercept

A

cytokine inhibitor

RA, JA, Psor Arth, plaq psor, AS

26
Q

Adalimumab

Infliximab

A

cytokine inhibitors
TNF-alpha blocker (-mabs)
inc risk of serious infn

27
Q

2 drugs for transplants

A

Cyclosporine

Tacrolimus

28
Q

2 alkylating agents for chemo

A

cisplatin

cyclophosphamide

29
Q

1 anthracycline for chemo

A

doxorubicin

30
Q

Anti-Her-2 chemo

A

trastuzumab

31
Q

Anti-metabolite/anti-folate for chemo

A

methotrexate

32
Q

Anti-microtubule for chemo

A

vinblastine

33
Q

Aromatase inhibitor for chemo

A

anastrozole

34
Q

non-steroidal androgen receptor blocker for chemo

A

bicalutamide

35
Q

LH-RH agonist/GnRH analogue for chemo

A

leuprolide

36
Q

Mitotic inhibitor for chemo

A

paclitaxel

37
Q

Pyrimidine analogue for chemo

A

5-fluorouracil

38
Q

SERMs for chemo

A

raloxifene

tamoxifen

39
Q

Polio doses

40
Q

Penuomococcal doses

41
Q

Meningococcal doses

A

1 at 11-12 yo

booster at 16 yo

42
Q

MMR

mumpes, measles, rubella

A

2

12-15 mo, 4-6 yrs

43
Q

HPV quad doses

A

3
11-12 yo, then 1-2 mo later, then 6 mo later
can’t use HPV2 for males

44
Q

HEP B doses

A

3

birth, 1-3 mo, 6-15 mo

45
Q

HEP A doses

A

2

12-23 mo, then 6-18 mo later

46
Q

HIB doses

A

3
2 mo, 4 mo, 6 mo
booster at 12-15 mo

47
Q

DPT doses

A

4 2 mo, 4, 6, 15 mo

2 boosters: adolesc, pregN

48
Q

Cholera doses

A

2 doses 1-6 wks apart no later than 2 wks before travel

2 yo + adult

49
Q

Adefovir dipivoxil

A

anti hepatitis B

nucleoside analogue

50
Q

anti hep B and C drug

A

interferon alpha 2
modulates immune system
SE: altered mental state, flulike, ai dz, psychotic

51
Q

Oseltamivir MOA

A

neuraminidase inhibitor
SE: suicide
Tamiflu

52
Q

Amantadine INDIC
MOA
SE

A

PD, and influenza A
MOA: inhibits viral uncoating
SE: neuroleptic malig syndrome, mental disorder

53
Q

Zidovudine (AZT) indic

A

HIV
nucleoside analogue, reverse transcriptase inhibitor
targets all cells
used in drug cocktail

54
Q

Bactrim

bacteriostatic

A

sulfamethoxazole - travel diarrhea, UTI, OM
PABA analogue/ antimetabolite
Trimethoprim - UTI, (SE is SJS)
folate analogue/antimetabolite

55
Q

nitrofurantoin

A

urinary tract
metabolite
CI pregn

56
Q

Fluoroquinolones are…
drugs?
SE

A

DNA synthesis inhibitors
cipro, levofloxacin
INdic: bacteriocidal, tx common infections, gram neg
SE: periph neuropathy, cartilage damage, prolonged QT

57
Q

Rifaximin

A

inhibits bacterial RNA

INDIC: IBD-D, hepatic enceoph

58
Q

Rifampin

A

inhibits RNA
INDIC TB
used with isoniazid, pyrazinamide

59
Q

Clindamycin

A

lincosamide
blocks peptide bonds
anaerobic infxn, broad spectrum
SE: C.diff, pseudomembranous colitis

60
Q

Macrolides drugs 3

A

Azithromycin
Erythromycin
Calrithromycin
Indic: pulm infxn, mycoplasma pneumonia, chlamydia
SE: prolonged QT, acute cholestatic hepatitis

*KS NPLEX ll (17 decks)

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