Misc

Question 1

Barbituates and what CI because why?

Answer 1

Barbs & Estrogen (OCP)

p450 enzyme inducer - pregN

Question 2

Steroids & what CI because why?

Answer 2

steroids and MAO-I

compete for p450 so risk of overdose

Question 3

Aspirin & what CI

Answer 3

if have gout, aspiring is CI because can cause increase in uric acid

Question 4

GFR level - when to make adjustments in medications

Answer 4

< 60

Question 5

Zero Order Elimination

Answer 5

once enzymes are saturated, the drug is excreted at a constant amt per unit time
vs First-Order Elimination - by %

Question 6

Aminoglycosides SE

Answer 6

ototoxicity

Question 7

Acetominophen Antidote

Answer 7

NAC

Question 8

Opiate antidote

Answer 8

naloxone

Question 9

Benzo antidote

Answer 9

Flumazenil

Question 10

Cyanide antidote

Answer 10

amyl nitrate

Question 11

Organophosphate antidote

Answer 11

atropine, pralidoxine

Question 12

Iron antidote

Answer 12

deferoxamine

Question 13

Heparin antidote

Answer 13

protamine

Question 14

ACh-r are what?

Answer 14

nicotinic muscarinic

Question 15

Acetycholine metabolism by what enzyme? what inhibits this enzyme?

Answer 15

acetylcholine esterase

bug killers –> tetany, cramps

Question 16

Adrenergic receptors are

Answer 16

alpha 1,2 beta 1,2

EPI, NE

Question 17

Cholinergic means

Answer 17

acts like ACh

Question 18

What does rauwolfia do?

Answer 18

decreases catcholamines (NE, SE) reserpine

Question 19

Chincona bark creates two drugs:

Answer 19

alkaloids
Quinine - anti-spasm, anti-pyr
Quinidine - antiarrthym (anticholinergic)

Question 20

Papaver

Answer 20

papaverine - alkaloid
vasodilation
tx angina
analgesic, blocks parasym

Question 21

Claviceps

Answer 21

ergot fungi
vasoconstrictive
bromocriptine - dopamine agonist

Question 22

Calabar

Answer 22

bean / physostigma
inhibits Ach esterase, so more ACh
parasympathomimetic

Question 23

Pylocarpus

Answer 23

cholinergic
parasympathomimetic
tx glaucoma (pupil constrict)