ImmunoTox

Question 1

Problem with terbinafine

Answer 1

takes a long time, LR damage

Question 2

Problem with Permethrin

indic?

Answer 2

scabies, lice – induces seizures

so also dangerous with kiddos

Question 3

Metronidazole
indic
CI

Answer 3

inhibits dna syn - protozoal
ameobas, trich, BV
CI w alcohol, LR failure

Question 4

SE is cinchonism

Answer 4

Hydroxychloroquine
looks like menieres
antimalarial

Question 5

Beta-lactamase producing bugs need to get hit by what drug?

Answer 5

Clavulanate + Penicillin
(augmentin)
cephalosproins are also Beta lactam

Question 6

if pt is allergic to Penicillin, dont give them_____

Answer 6

cephalosporins

Question 7

-ROMYCIN are?

Answer 7

macrolides
azithromycin
clarithromycin

Question 8

Which macrolide is mc used in PregN

Answer 8

azithromycin (also less GI SE)

clarithromycin is Category C

Question 9

Which antibiotic covers just about everything?

Answer 9

doxycylcine

Question 10

ADR of sulfamethoxazole / trimethoprim mycoplasma aka “Bactrim”

Answer 10

SJS, toxic epidermal necrolysis

RASH, SEIZURES

Question 11

Nitrofurantoin indic

probs

Answer 11

UTI - ecoli bc eliminated thru KD

last trimester can cause hemolysis in newborns

Question 12

Which drug if taken during the last trimester can cause hemolysis in newborns

Answer 12

nitrofurantoin

Question 13

Alternative to Penicillin

Answer 13

Clindamycin

gram +, anaerobes

Question 14

Achilles tendon rupture and tedonitis caused by what drug?

Answer 14

FLUOROQUINOLONES

ciprofloxacin

Question 15

Which drug inhibits growth plates so is CI in < 18 yo

Answer 15

FLUOROQUINOLONES

ciprofloxacin

Question 16

Tx for TB

Answer 16

rifampin for a LONG TIME up to 18 mo

Question 17

Rifampin ADR

Answer 17

LR toxicity, B6 depletion

Question 18

topical antibiotic that can cause a rash

Answer 18

neomycin

Question 19

MRSA prophylactic topical

Answer 19

mupirocin

Question 20

ADR of valacyclovir and other acyclovirs

Answer 20

NAUSEA, RASH

Question 21

Tamiful is the common name for

Answer 21

oseltamivir

Question 22

Humira name and type
INDIC
COMPLIC

Answer 22

Adalimumab / TNF blocker (slows down immune response)
INDIC: crohns, UC, Ank spondyl
COMPLIC: cancer, opportunistic infxn

Question 23

chemotherapy for breasts (Her2/neu- R blocker)

Answer 23

Trastuzumab

Question 24

proteins that protects neighbor cells from virus “surveillance)

Answer 24

interferon

Question 25

ADR of interferon

types alpha, beta, gamma tx what?

Answer 25

hypothyroid
alpha - hep b, c
beta - MS

Question 26

leukotriene antagonist that treats asthma

Answer 26

montelukast

Question 27

cell mediated immune response suppressor (like tacrolimus) but indic for the EYE
ADR?

Answer 27

cyclosporine

adr: kidney

Question 28

blocks T –> Estrogen so Txs breast CA and mets post-Op

Answer 28

Anastrazole

Question 29

chemotherapy drug DNA blocker with heart toxicity

Answer 29

DOXORUBICIN

Question 30

chemotherapy drug mitotic inhib

Answer 30

PACLITAXEL

VINBLASTINE

Question 31

serious ADR of doxorubicin, paclitaxel, vinblastine

Answer 31

bone marrow suppression

Question 32

dihydrofolate reductase inhibitor used as chemo, abortive agent, and for autoimmune conditions?

Answer 32

methotrexate

inhibits folic acid, thymidine, DNA

Question 33

Copper chelator for Wilson’s

Answer 33

PENICILAMINE

GI probs

Question 34

Lead chelator

Answer 34

EDTA
edetate calcium disodium
(hard on the kidneys)

Question 35

Iron Chelator

Answer 35

Deferoxamine

Question 36

Mercury chelator

ADR:

Answer 36

DMSA, DMPS
dithiols
ADR: low BP, low magnesium