Pharm I - Fleckenstein

Question 1

Define Pharmacokinetics

Answer 1

Actions the body has ON the drug

Question 2

Define Pharmacodynamics

Answer 2

Actions the drugs has ON the body

Question 3

Describe an Agonist

Answer 3

-A natural drug or Ligand -Activates receptor

Question 4

This is usually competes with the agonist with the binding site but does not activate the receptor

Answer 4

Antagonist (competitive inhibitor)

Question 5

In what direction does the antagonist usually shift the dose response curve?

Answer 5

To the right

Question 6

Describe an allosteric inhibitor

Answer 6

Binds to different site than agonist and antagonist. NONCOMPETITIVE And creates conformational change to receptor as to agonist can no longer bind

Question 7

What is a full agonist

Answer 7

High affinity for Ra. Ra-D complex favored, Larger effect observed

Question 8

Partial agonist

Answer 8

Intermediate affinity for Ra and Ri. Ra-D not stabilized as well than in Full agonist

Question 9

Inverse agonist

Answer 9

Higher affinity for Ri. DON’T confuse with Antagonist. Reduce constitutive activity

Question 10

What is a conventional antagonist

Answer 10

Equal affinity for Ra and Ri NO CHANGE in constitutive activity

Question 11

Which of the following drug receptor interaction has a net effect GREATER than the sum -Additive -Synergistic -Antagonistic

Answer 11

SYNGERSITIC (1+1 = 5) Additive - 1+1 = 2 Antagonistic 1+1 = 0.5

Question 12

This antagonist does not involve a receptor, a good example is a protein disrupting pH counteracting the effects of the drug

Answer 12

Chemical antagonist

Question 13

Define Efficacy

Answer 13

Number of receptos that must be activated to yeild max response

Question 14

How is potency different than efficacy?

Answer 14

Efficacy refers to the number of receptors where as potency refers to the amount of the drug needed. So a POTENT drug would require little dosage to illicit a max response.

Question 15

This is a measure of the drug’s ability to produce a change in cellular activity

Answer 15

Intrinsic activity

Question 16

This is a measure of the Tightness that a drug BINDS to the receptor

Answer 16

Affinity

Question 17

Define Therapeutic index

Answer 17

TI = TD(50)/ED(50) You want a large Toxic does over a small effective dose

Question 18

Define margin of safety

Answer 18

T.D (1%) / E.D. (99%)

Question 19

What is the fastest mode of mode of dosage for drugs

Answer 19

Intravenous or (Parenteral)

Question 20

Oral or Rectal administration is an example of ………

Answer 20

Enteral (by way of intestine)

Question 21

What is a disadvantage of oral administration (enteral)

Answer 21

Most unpredictable

Question 22

Which line is the most potent

Answer 22

Line B