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Pharmacology > ❤️pharm-Diuretics > Flashcards

❤️pharm-Diuretics Flashcards

1
Q

Furosemide
Bumetanide
Torsemide

A

Loop diuretics

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2
Q

Amiloride
Triamterine
Spironolactone**

A

Potassium-sparing diuretics

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3
Q

Hydrochlorothiazide
Indapamide
Chlorthalidone
Metolazone

A

Thiazide and thiazide-like diuretics

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4
Q

Thiazide & thiazides like

A

Work in the DCT
Used typically for BP reduction
Increase body retention of calcium
Vasodilator

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5
Q

All diuretics

A

Prevent salt reabsorption in the nephron
Increase urine output= lower fluid volume = lower BP
-short term: initial ⬇️ in plasma
-long term: ⬇️ in systemic vascular resistance

❤️ failure: removal of excess fluid volume

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6
Q

Thiazide side effects

A 
* ⬆️ calcium levels (hypercalcemia)
Hypovolemia
Hyperglycemia 
⬆️ cholesterol 
⬇️ potassium, mg 
Electrolyte imbalances 
Dizziness 
Dehydration 
Hypotension
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7
Q

Thiazide risk/ inx

A

Avoid with patients with renal failure
* sensitive to renal function

  • digoxin
  • lithium
  • Ace inhibitors
  • K supplements
  • NSAIDs
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8
Q

Thiazide MOA

A

Prevent salt and h20 reab in the nephron
Increase urine output= lower fluid volume= lower BP
Vasodilator
Used for BP reduction

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9
Q

Loops

A

Work in the LOH & blood vessels around LOH
Rid body of calcium
* increase volume output despite kidney fxn, better at lower fluid volume
* linear drug/dose response curve

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10
Q

Loops

AEs

A
  • hypocalcemia

Hyperglycemia, hypovolemia, Electrolyte imbalance, dizziness, dehydration, hypotension

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11
Q

Loops

Inx/risk

A 
Digoxin 
Lithium
K+ supplement 
Ace inhibitors 
* NSAIDs
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12
Q

Potassium sparing

A

Work in the DCT

  • ⬆️ serum potassium levels
  • low potency, used to correct side effects of other diuretics
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13
Q

Potassium sparing

AEs

A
  • hyperkalemia

Hyperglycemia, dizziness, dehydration, hypotension

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14
Q

Potassium sparing

Inx/risk

A 
Digoxin 
Lithium 
Ace inhibitors 
*NSAIDs 
* K supplements
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15
Q

What diuretic has a linear dose/response curve?

A

Loops

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16
Q

What diuretic can work to lower fluid volume despite kidney function?

17
Q

What diuretic is a vasodilator?

A

Thiazide/ thiazide like

18
Q

What diuretic is Lowe potency and used to correct side effects of other diuretics?

A

Potassium sparing

19
Q

What diuretic can cause hypercalcemia?

20
Q

What diuretic can cause hypocalcemia?

21
Q

What diuretic can cause hyperkalemia?

A

Potassium sparing

Pharmacology (23 decks)

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