❤️pharm- Aldosterone Antagonists

Question 1

Eplerenone

Spironolactone*

Answer 1

Aldosterone antagonist

Question 2

Aldosterone antagonists use what kind of dosing?

Answer 2

• target dose drug

Question 3

MOA
Aldosterone: causes the body to retain nacl and h20= ⬆️ blood volume= ⬆️ BP
And causes vessels to become fibrotic

Answer 3

By blocking the effects of aldosterone the body doesn’t retain nacl or water= lower blood volume= ⬇️ BP

Question 4

Aldosterone antagonists

Answer 4

May be better than ace and arbs in low renin HTN
More established in heart failure
-Lower salt and water retention
-lower vascular fibrosis

Question 5

Spironolactone*

Answer 5

K+ sparing diuretic

• non specific, blocks androgens
• lower in cost

Question 6

Spirinolactone

Side effects/risk

Answer 6

• gynecomastia- blocking androgens
• Hyperkalemia **
  Do not use if renal fxn is impaired
  -K supplement
  -k sparing diuretic
• CYP3A inhibitors (inx)

Question 7

Epleronone

Answer 7

Specific for aldosterone

• high in cost
• hyperkalemia
• don’t use if renal fxn is impaired
• K supplements
• k sparing diuretics
• CYP3A inhibitors inx

Question 8

How do aldosterone antagonists lower BP?

Answer 8

Blocking the body from retaining nacl & H20= ⬇️ blood volume= ⬇️ BP