Anti Seizure Drugs AEDs Flashcards
Complicated PK
High interaction risk
Most with cns depressing: learning and cognition
Older AEDs
Straight forward PK
Low drug interaction
Tolerated better than old AED
New AEDs
Complicated PK IV must be given slowly Auto inducer Severe skin reaction Fosphenytoin is prodrug
Phenytoin
Patients with Asian decent must have test done due to risk of skin infection
Carbamazepine
Old AED
Used only for absent seizures
Ethosuximide
Old AED
Phenytoin Carbamazepine Valproic acid Ethosuximide Phenobarbital Primidone
Old AEDs
Non seizure uses Pain Migraines Weight loss Kidney stones Medibolic acidosis
Topiramate
New AED
Rash is common
Lamotrigine
New AED
Common use for nerve pain
Nystagmus
Drowsiness
Gabapentin
New AED
Infantile spasms
Vision constriction
Vigabatrin
New AED
Aplastic anemia
Hepatotoxic it’s
Felbamate
Euphoria
Lacosamide
New AED
Fat soluble
Operate in CNS
Enhance GABA
Goal: stop the seizure
Cns: impaired speech, cognition
Dizziness, weakness
Suicide and pregnancy risk
All AEDs