❤️ Pharm- ACE Inhibitors

Question 1

Benzapril
Moexipril
Trandolapril
Captopril
Perindopril
Enlapril
Quinapril
Fosinopril
Ramipril

Answer 1

ACE Inhibitor

Question 2

Ace inhibitors

• 10
• “pril”
• target dose drug*

Answer 2

MOA: inhibit the conversion of ant1 to ant2

* no conversion= no vasoconstriction, no aldosterone. No salt/h20 retention

Question 3

Ace inhibitors

- side effects

Answer 3

• cough- bradykinin related
• renal dysfunction
• lower GFR
• lower kidney fxn
• risk of ARF
• hyperkalemia
• high in PTs with chronic kidney disease, using K sparing diuretic, K supplements

Question 4

Ace inhibitors

Inx/risk

Answer 4

• avoid in pregnancy
• k supplements (hyperkalemia)
• NSAIDs (with diuretic/ dehydration)
• inhibit PG fxn of vasodilation of afferent arteriole-vasoconstriction of aa= increase glomerular pressure= increase filtrate* bad for kidneys
• cyclosporine

Question 5

How do ace inhibitors lower BP?

Answer 5

By blocking the conversion of ant 1 to ant 2.

• blocks vasoconstriction, blocks aldosterone, inhibits sodium and water retention.
• ⬇️ BP by: vasodilation, lower aldosterone, preventing salt and water reabsorption.