Antispychotics

Question 1

Low impact on DA
Works as 5-HT antagonist
Low risk of EPS
High risk of metabolic effects
Act as a histamine, cholinergic, and andronergic receptor agonist
Effective
Effective against both positive and negative symptoms

Answer 1

Second generation-atypical

Question 2

EPS

Answer 2

Acute dystonia
Parkinsonism
Akathisia
Tardive dyskinesia

Question 3

Side effects: General to all antipsychotics

Answer 3

EPS

Neuroleptic malignant syndrome 
Anti cholinergic effects 
Orthostatic hypotension
Sedation 
Seizures 
Increased prolactin 
Sexual dysfunction 
QT prolongation- high risk with: chlorpromazine, thiorazidine, haloperidol, iloperidone, asenapine, pimozide

Question 4

Clozapine

Answer 4

Atypical-2nd generation
Very 1st drug
Most effective but has bad side effects
Agranulocytosis: close monitoring of wbc and anc
Weight gain: obesity, heart disease, diabetes mellitus

Question 5

Thiorazidine 
Chlorpromazine 
Perphenazine
Thiothixetine
Pimozide 
Haloperidol

Answer 5

First generation- typical antipsychotics

Question 6

Clozapine 
Risperidone
Paliperidone 
Apriprazole
Quetiapine
Ziprasidone
Olanzapine 
Iloperidone 
Asenapine 
Lurasidone
Brexpiprazole
Cariprazine

Answer 6

Second generation- atypical antipsychotics

Question 7

Main effects due to D2 antagonist actions
High risk of EPS
Effective on positive symptoms
Anti-dopamine
Acts as a histamine, cholinergic and andronergic receptor agonists
Effective

Answer 7

First generation- typical