❤️ Pharm- Calcium Channel Blockers

Question 1

Amilodipine
Nicardipine
Clevidipine
Nifedipine
Feldipine
Nimopidine
Isradipine
Nisoldipine

Answer 1

DHP

Calcium channel blockers

Question 2

Verampamil

Diltiazem

Answer 2

Non-DHP

Calcium channel blocker

Question 3

Calcium channel blockers

MOA

Answer 3

Inhibit transmembrane influx of calcium

• act on SA/AV node ( ⬇️ electrical conduction within the heart= lower contraction= ⬇️ BP
• vasodilator= ⬇️ HR= ⬇️ contractility= ⬇️ BP

Two types: DHP and non-DHP

Question 4

Side effects to all CA channel blockers

Answer 4

Headache
Flushing
Hypotension

Question 5

Side effects specific to non DHP

Answer 5

• constipation (CA)

* bradycardia, AV block, CHF

Question 6

Side effects specific to DHP

Answer 6

• pedal edema

* reflex tachycardia

Question 7

Non DHPs

• verapamil
• diltiazem

Answer 7

MOA: lower electrical conduction within the heart= lower force of contraction= ⬇️ HR = ⬇️ BP 
Work strictly on the heart 
-AV conduction ⬇️ 
-SA conduction ⬇️ 
-HR ⬇️

Question 8

Non DHP inx/risk

Answer 8

Can cause many drug interactions

* change metabolism/ transport of other drugs

Question 9

DHPs

-“INE”

Answer 9

• vasodilators* = ⬇️ BP
  Has no effect on the heart at all
• increases HR (reflex tachycardia)
  Subject to many drug inx (nifedipine, feladopine)
  -sensitive to changed caused by other drugs
• no effect on the heart in vivo

Question 10

How do calcium channel blockers lower BP?

Answer 10

1) lower electrical conduction at SA/AV node= lower contractility= lower HR = lower BP
2) vasodilation= lowers BP