❤️ Pharm- Beta-blockers

Question 1

Pindolol (ISA) 
Propranolol
Labetolol (a1 antagonist) 
Carvedilol (a1 antagonist) 
* both vasodilator a 
(PPLC)

Answer 1

Non selective Beta blockers

Question 2

Metoprolol
Nebivolol
Atenolol
Acebutolol
Bisoprolol
Esmolol
Betaxolol

Answer 2

Cardio selective Beta-blockers

Question 3

How do beta blockers lower BP?

Answer 3

By blocking the b1 & b2 receptors.

-⬇️ HR, ⬇️ contractility, ⬇️ renin & angiotensin 2: directly ⬇️ BP

Question 4

How do beta blockers work on heart failure?

Answer 4

Increase the hearts sensitivity to NE (which bind to b1 and b2)

Question 5

Blocking beta receptors causes what?

Answer 5

Lower HR
Lower contractility
Lower CO
= lower BP

Question 6

Beta blockers use what type of dosing?

Answer 6

Target dose

Start slow and increase slow until desired effect is reached

Question 7

Beta blocker side effects

Answer 7

• Bradycardia/ brady arrhythmia
• vasospasm-b2
  *bronchospasm- b2
• metabolic abnormalities: hyperglycemia/ ⬇️ insulin activity ( ⬇️ profusion)
  Depression
  Withdrawal
  Hypotension
• new diabetes

Question 8

Cardio selective beta blockers-7

“Lol”

Answer 8

Specific to b1 receptors
* antagonize b1 receptors (inhibit binding of NE)
Lower BP: ⬇️ HR, ⬇️ contractility, ⬇️ renin and angiotensin 2

❤️ failure: ⬆️ hearts sensitivity to NE to ⬆️ HR

Question 9

Non selective beta blockers-4

“Lol”

Answer 9

Antagonize both b1 and b2 receptors

• ⬇️ HR, ⬇️ contractility, ⬇️ renin and angiotensin 2
• by blocking b2 receptors- this causes Vado spams and bronchospasm- bad for ppl who have asthma and COPD