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PBL > PHARM 46 > Flashcards

PHARM 46 Flashcards

1
Q

cimetidine, ramitidine, famotidine, nizatidine are all what type of drugs?

A

H2 receptor blockers

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2
Q

Which H2 receptor antagonist is excreted almost entirely by renal?

A

Nizatidine

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3
Q

which H2 receptor antagonist inhibits p450 enzymes and hepatic metabolism of drugs?

A

Cimetidine

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4
Q

Omepraole, esomeprazole, rabeprazole,lansoprazole, dexlansoprazole, pantoprazole are examples of what kind of drugs?

A

Proton pump inhibitors

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5
Q

what is the active form of PPIs?

A

sulfanamide- activated by acidic enviorment and binds to cysteine residue

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6
Q

Which PUD drug allows continued use of NSAIDs?

A

PPIs

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7
Q

Dicyclomine is an example of what class of drugs

A

Anticholinergic

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8
Q

Which PPI is the most effective?

A

Esomeprazole

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9
Q

What 2 PPIs have a faster onset time?

A

rabeprazole and iansoprazole

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10
Q

Dicyclomine blocks what binding site?

A

acetylcholine

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11
Q

Antiacids, aluminum hydroxide, magnesium hydroxide do what?

A

neutralize HCl

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12
Q

Sodium bicarb and calcium carbonate differ how?

A

sodium bicarb is more soluble and reacts w HCl. Calcium carbonate reacts w gastric acid

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13
Q

Sucralfate and Colloidal bismuth belong to what class of drugs?

A

coating agents

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14
Q

coating agent that alters gastric pH

A

sucralfate

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15
Q

coating agent that forms a barrier which protects ulcers from further damage

A

colloidal bismuth

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16
Q

What class of drug is used specifically to treat NSAID induced ulcers?

A

Prostaglandins

17
Q

Analong of PG, used to prevent NSAID induced ulcer

A

misoprostol

18
Q

What is the triple therapy for H. pylori?

A

amoxicillin, clarithromycin, PPI

19
Q

What is the quadruple therapy?

A

tetracyclin, metronidazole, PPI, bismuth

20
Q

What H2 receptor has the highest bioavailability

A

nizatidine

21
Q

Which H2 receptor drug can be given IV

A

Ranitidine

22
Q

PPIs are metabolized in the liver by

A

CYP2C19 and CYP3A4

23
Q

What 2 drugs have drug-drug interxn concerns with PPIs?

A

ketoconazole and itraconazole – need acidic enviorment for uptake and PPI make it too alkaline

24
Q

Which antiacid can be used for treatment of pypepsia and ALSO osteoporosis?

A

calcium carbonate

25
Q

What is a contraindication of calcium carbonate?

A

severe renal insufficiency

26
Q

What is a contraindication of colloidal bismuth?

A

allergy to aspirin

27
Q

What can be used to treat IBS?

A

Dicyclomine (anticholenergic)

28
Q

What coating agent decreases effectiveness of quinolones?

A

sucralfate

29
Q

What coating agent decreases the absorption of tetracyclines?

A

colloidal bismuth

PBL (19 decks)

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