PHARM 46 Flashcards
cimetidine, ramitidine, famotidine, nizatidine are all what type of drugs?
H2 receptor blockers
Which H2 receptor antagonist is excreted almost entirely by renal?
Nizatidine
which H2 receptor antagonist inhibits p450 enzymes and hepatic metabolism of drugs?
Cimetidine
Omepraole, esomeprazole, rabeprazole,lansoprazole, dexlansoprazole, pantoprazole are examples of what kind of drugs?
Proton pump inhibitors
what is the active form of PPIs?
sulfanamide- activated by acidic enviorment and binds to cysteine residue
Which PUD drug allows continued use of NSAIDs?
PPIs
Dicyclomine is an example of what class of drugs
Anticholinergic
Which PPI is the most effective?
Esomeprazole
What 2 PPIs have a faster onset time?
rabeprazole and iansoprazole
Dicyclomine blocks what binding site?
acetylcholine
Antiacids, aluminum hydroxide, magnesium hydroxide do what?
neutralize HCl
Sodium bicarb and calcium carbonate differ how?
sodium bicarb is more soluble and reacts w HCl. Calcium carbonate reacts w gastric acid
Sucralfate and Colloidal bismuth belong to what class of drugs?
coating agents
coating agent that alters gastric pH
sucralfate
coating agent that forms a barrier which protects ulcers from further damage
colloidal bismuth
What class of drug is used specifically to treat NSAID induced ulcers?
Prostaglandins
Analong of PG, used to prevent NSAID induced ulcer
misoprostol
What is the triple therapy for H. pylori?
amoxicillin, clarithromycin, PPI
What is the quadruple therapy?
tetracyclin, metronidazole, PPI, bismuth
What H2 receptor has the highest bioavailability
nizatidine
Which H2 receptor drug can be given IV
Ranitidine
PPIs are metabolized in the liver by
CYP2C19 and CYP3A4
What 2 drugs have drug-drug interxn concerns with PPIs?
ketoconazole and itraconazole – need acidic enviorment for uptake and PPI make it too alkaline
Which antiacid can be used for treatment of pypepsia and ALSO osteoporosis?
calcium carbonate
