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PBL > PHARM 31 > Flashcards

PHARM 31 Flashcards

1
Q

Estogen agonist in bone, antagonist in endometrium and breast

A

Raloxifene

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2
Q

Alendronate, residronate, ibandronate, pamidronate, zoledronate are what class of drugs?

A

Bisphosphates (antiresorptive drugs)

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3
Q

What step in osteoclast function do bisphosphates block which causes apoptosis?

A

mevalonate pathway

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4
Q

Used to treat Paget’s disese?

A

aminobisphosphates

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5
Q

treats hypocalcemia

A

magnesium cholride

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6
Q

Denosumab is an example of

A

RANKL antagonist

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7
Q

increases trabecular bone mass while accelerating cortical bone loss

A

Fluoride

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8
Q

Once a day PTH causes

A

Increase bone remodeling

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9
Q

continuous exposure of PTH causes

A

bone catabolism

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10
Q

teriparatide

A

PTH 1-34 recombinante PTH

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11
Q

What are 3 approaches for preventing secondary hyperparathyroidism in chronic kidney disease?

A
  1. Oral phosphate binders
  2. calcitriol
  3. Calcimimetics
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12
Q

Precipitates PO4 in GI – treats hyperphosphatemia

A

alminum hydroxide

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13
Q

binds to dietary PO4 inhibiting its absorption

A

Calcium carbonate and calcium acetate

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14
Q

nonabsorable Ca ion exchange resin that binds intestinal phosphate and bile acid

A

Sevelamer

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15
Q

What do active vitamine D congeners by pass?

A

the need to be 1-alpha-hydroxylated in kidney

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16
Q

1-a hydroxylated form of D2 made active in liver

A

Doxercalciferol

17
Q

mechanisms that calcimimetics work by

A

bind to Ca receptors of cheif cells

18
Q

Used to treat hypocalcemic states associated with vitamin D dependent rickets and hypoparathyroidism

A

Calcium gluconate and CaCl

19
Q

Prevents osteoporosis or treat mild hypocalcemia

A

calcium citrate, calcium carbonate, calcium phosphate, calcium lctate

20
Q

What is the preferred method of treating hypoparathyroidism, rickets, etc?

A

Calcitriol– faster onset and offset, increase intestinal absorption of Ca

21
Q

What drugs require standing up right for 30 mins after administration?

A

Bisphosphates

22
Q

Bisphosphates only avalible in IV

A

Pamidronate and zoledronate

23
Q

RANKL antagonist contraindicated in hypocalcemia

A

denosumab

24
Q

phosphate binder that Requires acidic pH for absorption

A

calcium carbonate

25
Q

lowers serum cholesterol by binding bile salts in addition to phosphate

A

sevelamer

26
Q

Cholecalciferol aka

A

Vit D3

27
Q

ergocalciferol aka

A

Vit D2

28
Q

Calcifediol aka

A

25(OH)2D3

29
Q

Doxercalciferol aka

A

1-a-(OH)D2

30
Q

Calcimimetic that binds to Ca sensors in parathyroid cells– decrease PTH

A

Cinacalcet

PBL (19 decks)

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