PHARM 31

Question 1

Estogen agonist in bone, antagonist in endometrium and breast

Answer 1

Raloxifene

Question 2

Alendronate, residronate, ibandronate, pamidronate, zoledronate are what class of drugs?

Answer 2

Bisphosphates (antiresorptive drugs)

Question 3

What step in osteoclast function do bisphosphates block which causes apoptosis?

Answer 3

mevalonate pathway

Question 4

Used to treat Paget’s disese?

Answer 4

aminobisphosphates

Question 5

treats hypocalcemia

Answer 5

magnesium cholride

Question 6

Denosumab is an example of

Answer 6

RANKL antagonist

Question 7

increases trabecular bone mass while accelerating cortical bone loss

Answer 7

Fluoride

Question 8

Once a day PTH causes

Answer 8

Increase bone remodeling

Question 9

continuous exposure of PTH causes

Answer 9

bone catabolism

Question 10

teriparatide

Answer 10

PTH 1-34 recombinante PTH

Question 11

What are 3 approaches for preventing secondary hyperparathyroidism in chronic kidney disease?

Answer 11

1. Oral phosphate binders
2. calcitriol
3. Calcimimetics

Question 12

Precipitates PO4 in GI – treats hyperphosphatemia

Answer 12

alminum hydroxide

Question 13

binds to dietary PO4 inhibiting its absorption

Answer 13

Calcium carbonate and calcium acetate

Question 14

nonabsorable Ca ion exchange resin that binds intestinal phosphate and bile acid

Answer 14

Sevelamer

Question 15

What do active vitamine D congeners by pass?

Answer 15

the need to be 1-alpha-hydroxylated in kidney

Question 16

1-a hydroxylated form of D2 made active in liver

Answer 16

Doxercalciferol

Question 17

mechanisms that calcimimetics work by

Answer 17

bind to Ca receptors of cheif cells

Question 18

Used to treat hypocalcemic states associated with vitamin D dependent rickets and hypoparathyroidism

Answer 18

Calcium gluconate and CaCl

Question 19

Prevents osteoporosis or treat mild hypocalcemia

Answer 19

calcium citrate, calcium carbonate, calcium phosphate, calcium lctate

Question 20

What is the preferred method of treating hypoparathyroidism, rickets, etc?

Answer 20

Calcitriol– faster onset and offset, increase intestinal absorption of Ca

Question 21

What drugs require standing up right for 30 mins after administration?

Answer 21

Bisphosphates

Question 22

Bisphosphates only avalible in IV

Answer 22

Pamidronate and zoledronate

Question 23

RANKL antagonist contraindicated in hypocalcemia

Answer 23

denosumab

Question 24

phosphate binder that Requires acidic pH for absorption

Answer 24

calcium carbonate

Question 25

lowers serum cholesterol by binding bile salts in addition to phosphate

Answer 25

sevelamer

Question 26

Cholecalciferol aka

Answer 26

Vit D3

Question 27

ergocalciferol aka

Answer 27

Vit D2

Question 28

Calcifediol aka

Answer 28

25(OH)2D3

Question 29

Doxercalciferol aka

Answer 29

1-a-(OH)D2

Question 30

Calcimimetic that binds to Ca sensors in parathyroid cells– decrease PTH

Answer 30

Cinacalcet