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PBL > PHARM 42 > Flashcards

PHARM 42 Flashcards

1
Q

FLAP inhibitor

A

are not avalible (zileuton inhibits COX5 doee)

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2
Q

prednisone, pednisolone, dexamethasone are what class of drug?

A

Glucocorticoids

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3
Q

What do glucocorticoids activate?

A

annexins

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4
Q

Naproxen, salicylate, piroxicam, phenylbutazone are what kind of NSAIDs

A

LONG half lives

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5
Q

ibuprofen, naproxen, ketoprofen, and flurbiprofen are what class of drugs?

A

Propionic acid derivatives

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6
Q

What class of drugs are indomethacin, sulindac, etodolac, diclofenac, ketorolac

A

Acetic Acid derivatives

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7
Q

What is used for arthritis and musculoskeletal disorders?

A

Acetic acid derivatives

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8
Q

Piroxicam is in what drug class

A

Piroxicam

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9
Q

What inhibits oxidative burst?

A

prioxicam

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10
Q

Mefenamate and meclofenamate are both

A

fenamate derivatives

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11
Q

What is a ketone prodrug

A

Nabumetone (prefers to inhibit COX2)

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12
Q

Why is acetaminophen not an NSAID?

A

haves analgesic and antipyretic effects but no anti inflammatory

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13
Q

-xocibs are…

A

COX2 selective inhibitors

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14
Q

What drugs are contraindicated in by pass?

A

Celecoxib

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15
Q

Entanercept, infliximab, adalimumab, golimumab, certolizumab are

A

cytokine inhibitors – antibody based TNF-a antagonist

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16
Q

Anakira

A

IL-1 antagonist

17
Q

Dazoxibem and primagrel are both

A

inhibitors of thromboxane synthase

18
Q

Ridogrel is

A

TxA2 receptor antagonists

19
Q

zilueton inhibits COX5 from binding by:

A

chelating nonheme iron

20
Q

What is used to treat asthma induced by antigen, excercise, cold, or aspirin

A

CysLT1 receptor antagonists–

Montelukase Zafirlukast

21
Q

Irreversibly inhibits COX1 an COX 2

A

aspirin

22
Q

Can cause REyes syndrome

A

aspirin

23
Q

acetomeniphen blocks

A

COX3 in CNS no inflammatory, pain and heat

24
Q

What decreases efficacy of ACE inhibitors?

A

celecoxib

25
Q

What is given for matenance of patent ductus arteriosus?

A

Alprostadil

26
Q

What is the mechanism of prostanoids?

A

Agonist of prostanoid receptors

27
Q

Cytokine antagonist work by what mechanism?

A

all block TNF-a EXCEPT anakinra- IL-1

28
Q

What is used for abortion in 2nd third trimester and can be used to control postpartum bleeding?

A

Carboprost (PGF2a analog)

29
Q

PGF2a analogues that are ocular hypotensive agents?

A

Latanoprost, bimatoprost, travoprost

PBL (19 decks)

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