BIOCHEM 37

Question 1

Pepsinogen activated by

Answer 1

H+ in stomach acid

Question 2

Trypsinogen activated by:

Answer 2

enteropeptidase

Question 3

chymotrypsinogen activated by

Answer 3

trypsin

Question 4

proelastase activated by

Answer 4

trypsin

Question 5

procarboxypeptidase activated by

Answer 5

trypsin

Question 6

3 serine proteases

Answer 6

trypsin, chymotrypsin, elastase

Question 7

carboxyl provided by lysine or arginine cleaved by

Answer 7

Trypsin

Question 8

cleaves residues that contain hydrophobic AA (phenylalanine, tyrosin, trptophane, leucine)

Answer 8

Chymotrypsin

Question 9

Cleaves proteins at bonds where carboxyl is contributed by small side chain AA (Alanine, glycine, serine)

Answer 9

Elastase

Question 10

Emphysema is caused by:

Answer 10

mutation in alpha-1-antitrpsin which blocks elastase from digesting the lung cells

Question 11

Action of aminopeptidase

Answer 11

cleaves at N-terminal

Question 12

Action of carboxypeptidase A

Answer 12

cleaves at C- terminal of hydrophobic AA

Question 13

Action of carboxypeptidase B

Answer 13

Cleaves C terminal of Basic AA

Question 14

Primary transport mechanism of AA

Answer 14

Sodium gradient created by Na+, K+ ATPase

Question 15

Secondary transport mechanism of AA

Answer 15

coupling of AA to influx of Na+

Question 16

Hartnup Disease:

Answer 16

defect in B0 membrane transport protein for neutral AA (tryptophan– pellegra like syndrome)

Question 17

Cystinuria

Answer 17

defect in B0+ membrane transport protein for basic AA –> cystine concentrated in kidney and liver = stones