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PBL > PHARM 27 > Flashcards

PHARM 27 Flashcards

1
Q

Concentrates Iodide on basolateral membrane of follicular cells

A

NIS (na/I symporter)

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2
Q

organification

A

thyroglobulin iodination –> MIT and DIT

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3
Q

catalyzes t4 –> T3

A

iodothyronine 5’ deiodinase

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4
Q

Deiodinase that is expressed in liver and kidneys, coverts serum T4

A

Type I

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5
Q

Deiodinase expressed in pituitary gland, brain, and brown fat converts T4 locally

A

Type II

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6
Q

Converts T4 - rT3

A

Type III Deiodinase

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7
Q

Two types of thyroid hormone receptors

A

alpha and beta

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8
Q

TR react with this to form heterodimers

A

retinoid X receptor RXR

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9
Q

TSH producing cells

A

thyrotropes

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10
Q

thryoid stimulating immunoglobulin

A

IgG autoantibody specific for TSH receptor

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11
Q

L-isomer of T4

A

levothyroxine

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12
Q

how does increase of hepatic p450 effect thyroid hormone?

A

it increases excretion

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13
Q

Perchlorate, thiocyanate, pertechnetate are what class of drugs

A

Inhibitors of iodide uptake – compete for iodide uptake into thyroid gland follicular cell

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14
Q

What radioactive Iodine is used as radiative treatment of hyperthyroidism?

A

131 I-

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15
Q

What is the Wolff-Chaikoff effect?

A

high levels of iodide inhibit thyroid hormone synthesis and release

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16
Q

Propylthiouracil and methimazole are what kind of drugs

A

Thioamines that compete with thyroglobulin for iodide – decrease organification

17
Q

drugs that cause goiter

A

goitrogens (thioamines bc no thyroid hormone= TSH stimulation)

18
Q

Inhibits thyroid peroxidase as well as peripheral T4 –> T3

A

propylthiouracil

19
Q

only inhibits thyroid peroxidase and not peripheral T3 conversion

A

methimazole

20
Q

Preferred b-antagonist for treatment of thyroid storm

A

esmolol

21
Q

5’ deiodinase inhibitor

A

Ipodate

22
Q

How does amiodarone cause hypothyroidism?

A

metabolism releases iodide which concentrates in thyroid gland –> wolff- Chaikoff effect

23
Q

Type 1 thyrotoxicosis via amiodarone

A

excess iodide = increase thyroid hormone increase and release

24
Q

type 2 thyrotoxicosis via amiodarone

A

autoimmune throiditis induced –> excess thyroid hormone from colloid

25
Q

Amiodarone intrxn w 5’ deiodinase

A

competatively inhibits and reduces peripheral T3 conversion

26
Q

L- analog of T3

A

Liothyronine

27
Q

Rifampin and phenytoin increases the metabolism of what drug

A

synthetic thyroid hormone

28
Q

Cholestyramine and sodium polystyrene sulfonate decrease the absorption of what drug

A

synthetic thyroid hormone

29
Q

Used in hyperthyroidism but risk developing aplastic anemia

A

Percholorate
thiocyanate
pertechnetate

30
Q

Used as an alternative to surgical treatment of hyperthyroidism

A

131 I- (may worsen ophthalmopathy

PBL (19 decks)

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