IMMUNO Flashcards
Secreted by: maacrophages and T cells
TNF
Secreted by Marcrophages endothelial cells
IL-1
Secreted by macrophages, dendritic cells, endothelial cells, T lymphocytes, fibroblast, platelets
Chemokine
Secreted by dendritic cells and macrophages
IL-12
secreted by NK cells and T lymphocytes
IFN y
IFN-a is secreted by
dendritic cells and macrophages
IFN-B is secreted by
fibroblasts
secreted by dendritic cells macrophages and t cells
IL-10
Secreted by macrophages, endothelial cells, T cells
IL-6
IL-15 secreted by
macrophages
IL-18 secreted by
macrophages
Inhibits inflammation
differentiation of Th17
regulatory T cells
TGF-B
NK and T cell proliferation
IL15
Stimulates liver to synthesis acute phase proteins
B cells: proliferation of Ab producing cells
IL6
Inhibits IL-12 production and reduced expression of costimulator and class II MHC
IL10
Activation of macrophages
IFN-y
stimulates leukocytes: increased integrin affinity, chemotaxis, activation
Chemokines
Endothelial cells: activation
Fever
Liver: acute phase proteins
TH17 differentiation
IL-1
Muscle, fat: catabolism apoptosis of cells endothelial activation neutrophil activation syn of acute phase proteins
TNF
C3a of complement stimulates
inflammation
C3b of complemnet stims
opsonization and pagocytosis
C5a stimulates
inflammation
Plasma TLR
1,2,4,5,6
Endosome TLR
3789
TLR 1 and 2 and 6
Bacterial lipopeptides
TLR-2
bacterial peptidoglycans
TLR-4
LRS
TLR-5
bacterial flagellin
