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Pharm Flashcards

1
Q

What is the equation for Volume of distribution?

A

Vd = amount of drug in body/plasma drug concentration

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2
Q

What is the equation for half-life?

A

t 1/2 = (0.693 x Vd) / CL

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3
Q

What is the equation fro clearance?

A

CL = rate of elim/ plasma drug conc = Vd x Ke

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4
Q

What is the equation for loading dose?

A

Loading dose = (Cp x Vd) / F

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5
Q

What is the equation for maintenance dose?

A

Maintenance dose = (Cp x CL x tau) / F = Css x CL

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6
Q

What drugs cause coronary vasospasm?

A

Cocaine, sumatriptan, ergot alkaloids, amphetamines

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7
Q

What drugs cause cutaneous flushing?

A

VANC: Vancomycin, Adenosine, Niacin, Calcium channel blockers

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8
Q

What drugs cause dilated cardiomyopathy?

A

Doxorubicin, daunorubicin

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9
Q

What drugs cause Torsades de pointes?

A

Class III and class IA antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs, antimalarial

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10
Q

What drugs cause hot flashes?

A

Tamoxifen, clomiphene

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11
Q

What drugs cause Hypothyroidism?

A

Lithium, Amiodarone, Sulfonamides

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12
Q

What drugs cause hypoglycemia?

A

Tacrolimus, Protease inhibitors, Niacin, HCTZ, B-blockers, Corticosteroids (Taking Pills Necessitates Having Blood Checked)

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13
Q

What drugs cause gynecomastia?

A

Spironolactone, Ketoconazole, estrogens, cimetidine, alcohol, marijuana

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14
Q

What drugs cause acute cholestatic hepatitis, jaundince?

A

Erythromicin

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15
Q

What drugs cause diarrhea?

A

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose (Might Excite Colon On Accident)

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16
Q

What drugs cause Focal to massive hepatic necrosis?

A

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (Liver “HAVAc”)

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17
Q

What drug can cause hepatitis?

A

INH

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18
Q

What drugs can cause pancreatitis?

A

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (Drugs Causing A Violent Abdominal Distress)

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19
Q

What drugs cause agranulocytosis?

A

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil (Drugs CCCrush Myeloblasts and Promyelocytes)

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20
Q

Waht drugs cause Aplastic anemia?

A

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propyltiouracil (Can’t Make New Blood Cells Properly)

21
Q

What drugs cause Direct Coombs-positive hemolytic anemia?

A

Methyldopa, penicillin

22
Q

What drugs causes gray baby syndrome?

A

Chloramphenicol

23
Q

What drugs cause hemolysis in G6PD deficiency?

A

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin & Fava beans (Hemolysis IS D PAIN)

24
Q

What drugs cause Megaloblastic Anemia?

A

Phenytoin, Methotrexate, Sulfa drugs (Having a blast with PMS)

25
Q

What drugs can cause thrombocytopenia?

A

Heparin, cimetidine

26
Q

What drugs can cause fat redistributions?

A

Protease inhibitors, Glucocorticoids (Fat PiG)

27
Q

What drugs cause gingival hyperplasia?

A

Phenytoin, verapamil, cyclosporine, nifedipine

28
Q

What drugs cause Hyperuricemia?

A

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine (Painful Tophi and Feet Need Care)

29
Q

What drugs can cause myopathy?

A

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids

30
Q

What drugs cause osteoporosis?

A

Corticosteroids, heparin

31
Q

What drugs cause photosensitivity?

A

Sulfonamides, Amiodarone, Tetracyclines, 5-FU (SAT For Photo)

32
Q

What drugs cause rash?

A

Anti-epileptic drugs, allopurinol, sulfa drugs, penicillin

33
Q

What drugs cause SLE-like syndrome?

A

Sulfa drugs, Hydralazine, INH, Procainaminde, Phenytoin, Etanercept (Having lupus is “SHIPP-E”)

34
Q

What drugs cause teeth discoloration

A

Tetracyclines

35
Q

What drugs cause tendonitis, tendon rupture, and cartilage damage?

A

Fluoroquinolones

36
Q

What drugs cause cinchonism?

A

Quinidine, quinine

37
Q

What drugs cause Parkinson-like syndrome?

A

Antipsychotics, Reserpine, Metoclopramide (Cogwheel rigidity of ARM)

38
Q

What drugs can cause seizures?

A

INH, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (With seizures, I BITE My tongue

39
Q

What drugs cause tardive dyskinesia?

A

Antipsychotics, metoclopramide

40
Q

What drugs cause Diabetes insipidus?

A

Lithium, demeclocycline

41
Q

What drugs cause Fanconi syndrome?

A

Expired tetracycline (proximal tube defect)

42
Q

What drugs cause hemorrhagic cystitis?

A

Cyclophosphamide, ifosfamide (Prevent with Mesna)

43
Q

What drugs cause interstitial nephritis?

A

Methicillin (and other Abx), NSAIDs, and Furosemide

44
Q

What drugs can cause SIADH?

A

Carbamazepine, Cyclophosphamide, SSRIs (Can’t Concentrate Serum Sodium)

45
Q

What drugs cause a dry cough?

A

ACE inhibitors

46
Q

What drugs cause pulmonary fibrosis?

A

Bleomycin, Amiodarone, Busulfan, Methotrexate

47
Q

What drugs have antimuscarinic side effects?

A

Atropine, TCAs, H1-blockers, antipsychotics

48
Q

What drugs have a disulfiram-like reaction?

A

Metronidazole, certain Cephalosporins, Griseofulvin, Procarbazine, 1st-gen sulfonylureas

49
Q

What drugs have nephrotoxicity/ototoxicity?

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

Step 1 (17 decks)

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