Path Flashcards
What is the difference in collagen fibers between a hypertrophic scar and a keloid?
Keloid - parallel fibers. Hypertrophoc scar - disorganized.
PDGF. Go.
Secreted by activated paltelets and macrophages. Induces vascular remodeling and smooth muscle cell migration. Stimulates fibroblast growth.
FGF. Tell me bout it.
Stimulates all aspects of angiogenesis.
EGF. What it is?
Stimulates cell growth via tyrosine kinases
What does TGF-beta stimulate?
Angiogenesis, fibrosis, cell cycle arrest
What is diabetes-related amyloid composed of?
B2-microglobulin. May present as carpal tunnel.
What neoplasm is associated with Cushing syndrome?
Small cell lung carcinoma
What neoplasm is associated with dermatomyositis?
Lung cancer
What neoplasm is associated with myasthenia gravis & pure RBC aplasia?
Thymoma
What neoplasm is associated wiht Plummer-vinson syndrome?
Squamous cell carcinoma of esophagus (PV has decreased iron)
In what conditions are Psammoma bodies seen?
Papillary carcinoma of thyroid, serous papillary cystadenocarcinoma of ovary, Meningioma, Malignant Mesothelioma (PSaMMoma)
What is the most common primary tumor site for liver metastases?
Colon»_space; stomach > pancreas
What are the most common primary tumor sites for bone metastases?
Prostate/breast > lung > thyroid
