Pharm 11: Adrenergic

Question 1

Dopamine is hydroxilated to yield _________

Answer 1

NorEpi

Question 2

Dopamine is transported into synaptic vessels by

Answer 2

VMAT

Question 3

Cocaine MOA

Answer 3

inhibits norepi transporter

This transporter brins norepi back into the neuron

Question 4

Reserpine MOA

Answer 4

Blocks VMAT so norepi cannot be transported into vesicles

Question 5

alpha adrenergic receptors signaling mediators

Answer 5

Gq/Gi/Go

Question 6

beta adrenergic signaling mediator (receptor type)

Answer 6

Gs

Question 7

α1 receptor tissues and effects

Answer 7

Vascular smooth muscle = contraction
Intestinal smooth muscle = relaxation
Heart = increased inotropy and excitability
Liver: glycogenolysis and gluconeogenesis

Question 8

α2receptor tissues and effects

Answer 8

Pancreatic B cells = decreased insulin secretion
Platelet = aggregation
Nerves = decreased norepi release (feedback)
Vascular smooth muscle = contraction

Question 9

β1 receptor tissues and effects

Answer 9

Heart = dromotropy, inotropy, chronotropy
Kidneys = renin secretion

Question 10

β2 receptor tissues and effects

Answer 10

Smooth muscle = relaxation (albuterol)
Liver= glycogenolysis and gluconeogenesis
Muscle = K+ uptake (albuterol for hyperk)

Question 11

β3 receptor tissue and effect

Answer 11

Adipose tissue lipolysis

Question 12

Epinephrine MOA

Answer 12

agonist of both α and β. Mostly β at low concentrations

Question 13

Norepi MOA

Answer 13

β1 and α1 but not β2

Question 14

Dopamine MOA

Answer 14

Low doses acts on D receptors

High doses acts on β1 receptors

Higher even doses it starts hitting α1

Question 15

α-methyltyrosine MOA

Answer 15

inhibits catecholamine synthesis

used to treat pheochromocytoma associated HTN

Question 16

Tyramine MOA

Answer 16

Gets taken up into synaptic vesicles, displacing norepi. Norepi. in short term causes hypertension. Long term hypotension

Question 17

Octopamine MOA

Answer 17

Metabolite of tyramine. Doesnt cause hypertension initially but retains the chronic hypotension

Question 18

Guanethidine MOA

Answer 18

actively transported by NET into neurons, displacing norepi

Question 19

Amphetamine MOA

Answer 19

ADDERALL BB

Question 20

Phenylephrine MOA

Answer 20

α1 agonist used IN to vasoconstrict and reduce nasal congestion

Question 21

Clonidine MOA and use

Answer 21

α2 agonist.

used to lower sympathetic activity in brain stem

decreases norepi release

Question 22

Dexmedetomine MOA

Answer 22

α2 receptor agonist

decreases sympathetic activity causes sedation

Question 23

α-Methyldopa MOA and use

Answer 23

Prodrug that metabolizes to α2 agonist. Lowers blood pressure

used only in pregnancy

Question 24

Isoproterenol MOA

Answer 24

non selective β agonist

Increases CO with little increased BP

Question 25

Dobutamine MOA and use

Answer 25

Isomer properties cancel each other. Effectively a β1 agonist.

Inotrope and chronotrope

Used for heart failure IV

Question 26

β2 agonists

Answer 26

Terbutaline and albuterol

also salmeterol as long acting

Question 27

Terazosin, prazosin, doxazosin MOA and use

Answer 27

α1 antagonist. Used for treatment of hypertension

Question 28

Yohimibine MOA and use

Answer 28

α2 selective blocker. Increased norepi release. Gives you a boner. Kinda useless tho

Question 29

Non selective β blockers

Answer 29

PNT

Propranolol

Nadolol

Timolol

Question 30

Propranolol MOA and use

Answer 30

non selective beta blocker

used for hypertension and coronary artery disease

Question 31

Drugs that are nonselective beta blockers and also α1 antagonists

Answer 31

Labetalol

Carvedilol

Question 32

β1 selective antagonists

Answer 32

EMAC

Esmolol

Metoprolol

Atenolol

Celiprolol

Question 33

Treatment for benign prostatic hyperplasia

Answer 33

Tamsulosin

α1a blocker

Question 34

Acebutolol MOA

Answer 34

partial β1agonist

Used for ischemic heart disease with heart failure

Question 35

Buzzword: intrinsic sympathomemetic activity

Answer 35

Think partial agonist