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PBL 2: Remediation Boogaloo > Immuno 6: T cell mediator mechanisms > Flashcards

Immuno 6: T cell mediator mechanisms Flashcards

1
Q

What type of T Cell recruit other lymphocytes?

A

CD4+ Helper T cells

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2
Q

What type of T Cells kill infected cells?

A

CD8+ cytotoxic T cells

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3
Q

IgE activates what type of cells?

A

Eosinophils

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4
Q

Th1 T cells defining cytokine

A

IFN-gamma

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5
Q

Th1 T cell principal target and reaction

A

Macrophages

Macrophage activation to kill ingested pathogens

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6
Q

Th1 T cells intended defense target

A

Intracellular pathogens in phagocytes

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7
Q

Th2 cells defining cytokines

A

IL-4
IL-5
IL-13

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8
Q

Th2 cells target and reaction

A

Eosinophil and mast cell activation

Alternative macrophage activation

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9
Q

Th2 cells intended defense target

A

Helminths (WORMIES)

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10
Q

Th17 defining cytokines

A

IL-17 (interleukin)
IL-22

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11
Q

Th17 target and reaction

A

Neutrophil recruitment and activation

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12
Q

Th 17 intended defense target

A

Extracellular bacteria and fungi

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13
Q

Tfh defining cytokine

A

IL-21

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14
Q

Tfh principal target and immune reaction

A

B Cells

Antibody production

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15
Q

Tfh defense target

A

Extracellular pathogens

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16
Q

Classical Macrophage activation steps

A

1) Macrophage ingests pathogen
2) Macrophage presents antigens from pathogen on cell surface (MHC 2)
3) TH1 T Cells binds to presented antigen
4) Th1 produces CD40L and IFN-gamma
5) CD40L binds to macrophage CD40 together with IFN-gamma causes macrophage to produce substances that kill the pathogen

17
Q

Th2 cells inhibit ______ and instead stimulate ______________

A

Th2 cells inhibit classical macrophage activation and instead stimulate the alternative macrophage pathway

18
Q

Alternative macrophage activation purpose

A

Tissue repair, enhanced fibrosis

19
Q

What stimulates naive CD4+ cells to become Th2 cells?

A

IL-4

20
Q

IFN-Gamma inhibits

A

Th2 and Th17 cell production

21
Q

Lepromatous leprosy is associated with

A

Decreased Th1 activation

22
Q

Tuberculoid leprosy is associated with

A

Increased Th1 activation

23
Q

Defensin production is stimulated by

A

IL-22 from Th17 cells

24
Q

IL-17 induces

A

Chemokine production which in turn recruits leukocyte

25
Q

Th17 development from naive CD4+ cells comes from

A

Cytokines produces by dendritic cells

26
Q

What happens when a CD8+ cytotoxic T cell binds to an infected cell?

A

1) Exocytosis of CD8+ granules into synapse
2) Perforin granules open cell membrane
3) Granzymes enter the cell
4) Granzymes activate caspases
5) Caspases induce apopstosis

PBL 2: Remediation Boogaloo (24 decks)

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